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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased regulatory T cell number
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Accession:MP:0004974 term browser browse the term
Definition:reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
Synonyms:exact_synonym: decreased Treg cell number;   decreased suppressor T cell number;   reduced Treg cell number;   reduced regulatory T cell number


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decreased regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) IAGP MGI PMID:21300913 NCBI chr10:77,865,856...77,879,444
Ensembl chr10:77,865,856...77,879,444 		JBrowse link
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 IEA MGI NCBI chr 4:32,238,413...32,586,109
Ensembl chr 4:32,238,804...32,586,108 		JBrowse link
G Bcl2a1a B cell leukemia/lymphoma 2 related protein A1a IAGP MGI PMID:28085150 NCBI chr 9:88,838,973...88,844,469
Ensembl chr 9:88,838,953...88,844,472 		JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b IAGP MGI PMID:28085150 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880 		JBrowse link
G Bcl2a1d B cell leukemia/lymphoma 2 related protein A1d IAGP MGI PMID:28085150 NCBI chr 9:88,605,341...88,613,903
Ensembl chr 9:88,605,338...88,613,967 		JBrowse link
G Card11 caspase recruitment domain family, member 11 IAGP MGI PMID:19260764 NCBI chr 5:140,858,754...140,986,351
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 IAGP MGI PMID:23793062 NCBI chr 8:106,412,642...106,424,827
Ensembl chr 8:106,412,906...106,424,819 		JBrowse link
G Cd1d1 CD1d1 antigen IAGP MGI PMID:16339525 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd27 CD27 antigen IAGP MGI PMID:23547099 NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973 		JBrowse link
G Cd28 CD28 antigen IAGP MGI PMID:15467837 PMID:23065717 PMID:23281398 PMID:23793062 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cd40lg CD40 ligand IAGP MGI PMID:15467837 NCBI chr  X:56,257,503...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cd70 CD70 antigen IAGP MGI PMID:23547099 NCBI chr17:57,452,997...57,456,777
Ensembl chr17:57,452,997...57,456,777 		JBrowse link
G Cd80 CD80 antigen IAGP MGI PMID:16886063 PMID:23793062 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697 		JBrowse link
G Cd86 CD86 antigen IAGP MGI PMID:15467837 PMID:16886063 PMID:23793062 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Dicer1 dicer 1, ribonuclease type III IAGP MGI PMID:18725525 PMID:18725527 NCBI chr12:104,653,999...104,718,227
Ensembl chr12:104,654,001...104,718,211 		JBrowse link
G Drosha drosha, ribonuclease type III IAGP MGI PMID:18725527 NCBI chr15:12,824,893...12,935,377
Ensembl chr15:12,824,901...12,935,377 		JBrowse link
G E2f1 E2F transcription factor 1 IAGP MGI PMID:15470032 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Fads1 fatty acid desaturase 1 IAGP MGI PMID:22534642 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241 		JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:18209052 PMID:20072126 PMID:21460251 PMID:23281398 PMID:27410049 More... NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fyn Fyn proto-oncogene IAGP MGI PMID:19668367 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
G Gpr15 G protein-coupled receptor 15 IAGP MGI PMID:23661644 NCBI chr16:58,537,006...58,539,235
Ensembl chr16:58,537,796...58,539,433 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:18354198 PMID:23065717 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 IAGP MGI PMID:23712430 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Ier3 immediate early response 3 IAGP MGI PMID:19923449 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta IAGP MGI PMID:14499113 NCBI chr 8:23,149,221...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma IEA MGI NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Ikzf4 IKAROS family zinc finger 4 IAGP MGI PMID:31296356 NCBI chr10:128,466,708...128,505,668
Ensembl chr10:128,466,712...128,505,227 		JBrowse link
G Il15 interleukin 15 IAGP MGI PMID:23805138 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain IAGP MGI PMID:16227983 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain IAGP MGI PMID:12196288 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il2rg interleukin 2 receptor, gamma chain IAGP MGI PMID:19528538 PMID:23109710 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861 		JBrowse link
G Itgav integrin alpha V IAGP MGI PMID:17895374 NCBI chr 2:83,551,625...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Lat linker for activation of T cells IAGP MGI PMID:18209052 PMID:19380807 NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 IAGP MGI PMID:18282810 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:28533230 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 IAGP MGI PMID:17060023 NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298 		JBrowse link
G Marchf1 membrane associated ring-CH-type finger 1 IAGP MGI PMID:23712430 NCBI chr 8:66,070,550...66,925,761
Ensembl chr 8:66,070,552...66,924,289 		JBrowse link
G Mir125a microRNA 125a IAGP MGI PMID:25963922 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141 		JBrowse link
G Mir155 microRNA 155 IAGP MGI PMID:19234151 PMID:26163372 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Myct1 myc target 1 IAGP MGI PMID:33658356 NCBI chr10:5,543,728...5,556,789
Ensembl chr10:5,543,775...5,556,904 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEA MGI NCBI chr 1:152,675,904...152,712,741
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 IAGP MGI PMID:19060899 PMID:24652767 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha IAGP MGI PMID:21333553 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IAGP MGI PMID:21468021 NCBI chr 2:56,996,845...57,014,018
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 IAGP MGI PMID:28294127 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519 		JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 IAGP MGI PMID:28294127 NCBI chr 5:136,176,310...136,201,418
Ensembl chr 5:136,176,313...136,199,567 		JBrowse link
G Otud5 OTU domain containing 5 IAGP MGI PMID:25470037 NCBI chr  X:7,705,852...7,742,865
Ensembl chr  X:7,707,603...7,742,865 		JBrowse link
G Pclaf PCNA clamp associated factor IEA MGI NCBI chr 9:65,797,605...65,810,833
Ensembl chr 9:65,797,519...65,810,548 		JBrowse link
G Pdcd1 programmed cell death 1 IAGP MGI PMID:22949674 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE type zinc finger containing IAGP MGI PMID:28533230 NCBI chr 1:65,225,796...65,317,855
Ensembl chr 1:65,225,842...65,317,854 		JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma IAGP MGI PMID:27313209 NCBI chr10:127,032,936...127,047,508
Ensembl chr10:127,032,936...127,047,454 		JBrowse link
G Plcg1 phospholipase C, gamma 1 IAGP MGI PMID:20123962 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Rwdd1 RWD domain containing 1 IEA MGI NCBI chr10:33,872,551...33,895,612
Ensembl chr10:33,872,551...33,895,620 		JBrowse link
G Septin9 septin 9 IAGP MGI PMID:23644740 NCBI chr11:117,090,487...117,253,151
Ensembl chr11:117,090,487...117,253,151 		JBrowse link
G Sik3 SIK family kinase 3 IEA MGI NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492 		JBrowse link
G St14 suppression of tumorigenicity 14 (colon carcinoma) IAGP MGI PMID:24551030 NCBI chr 9:30,999,886...31,043,138
Ensembl chr 9:31,000,698...31,043,149 		JBrowse link
G Stim1 stromal interaction molecule 1 IAGP MGI PMID:18327260 NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526 		JBrowse link
G Stim2 stromal interaction molecule 2 IAGP MGI PMID:18327260 NCBI chr 5:54,155,865...54,278,399
Ensembl chr 5:54,155,841...54,278,399 		JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 IAGP MGI PMID:22561606 NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II IAGP MGI PMID:23569233 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Thbs1 thrombospondin 1 IAGP MGI PMID:19700744 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Themis thymocyte selection associated IAGP MGI PMID:19597497 PMID:19597498 NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 IAGP MGI PMID:19668367 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 IAGP MGI PMID:26195727 NCBI chr 1:192,857,812...192,883,854
Ensembl chr 1:192,857,761...192,884,011 		JBrowse link
G Trim56 tripartite motif-containing 56 IEA MGI NCBI chr 5:137,140,140...137,145,313
Ensembl chr 5:137,134,498...137,145,063 		JBrowse link
G Usp17lc ubiquitin specific peptidase 17-like C IAGP MGI PMID:22984479 NCBI chr 7:103,065,903...103,068,381
Ensembl chr 7:103,064,279...103,069,087 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IAGP MGI PMID:17959935 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Was Wiskott-Aldrich syndrome IAGP MGI PMID:17878299 NCBI chr  X:7,947,705...7,956,730
Ensembl chr  X:7,947,692...7,956,737 		JBrowse link
G Wasl WASP like actin nucleation promoting factor IAGP MGI PMID:17878299 NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008 		JBrowse link
G Xcl1 chemokine (C motif) ligand 1 IAGP MGI PMID:21300913 NCBI chr 1:164,759,213...164,763,091
Ensembl chr 1:164,759,213...164,763,096 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IAGP MGI PMID:19841086 NCBI chr 1:36,800,879...36,821,902
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
G Zfp335 zinc finger protein 335 IAGP MGI PMID:25343476 NCBI chr 2:164,733,802...164,756,034
Ensembl chr 2:164,733,802...164,753,677 		JBrowse link
absent regulatory T cells term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Commd10 COMM domain containing 10 IAGP MGI PMID:29127143 NCBI chr18:47,091,886...47,221,062
Ensembl chr18:47,091,883...47,367,351 		JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:16275384 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 IAGP MGI PMID:16940043 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Satb1 special AT-rich sequence binding protein 1 IAGP MGI PMID:29127143 NCBI chr17:52,043,215...52,140,318
Ensembl chr17:52,043,215...52,140,318 		JBrowse link
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper transcription factor, ATF-like IAGP MGI PMID:20421391 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Card11 caspase recruitment domain family, member 11 IEA MGI NCBI chr 5:140,858,754...140,986,351
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Cd38 CD38 antigen IEA MGI NCBI chr 5:44,026,151...44,069,716
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Diaph1 diaphanous related formin 1 IEA MGI NCBI chr18:37,976,654...38,068,573
Ensembl chr18:37,976,654...38,068,529 		JBrowse link
G Elmo1 engulfment and cell motility 1 IEA MGI NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523 		JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:12612578 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
G Gmnn geminin IAGP MGI PMID:20107189 NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 IAGP MGI PMID:16709807 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta IAGP MGI PMID:33658989 NCBI chr 8:23,149,221...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 IEA MGI NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926 		JBrowse link
G Itk IL2 inducible T cell kinase IEA MGI NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 IAGP MGI PMID:26132627 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A IAGP MGI PMID:19679885 NCBI chr  X:163,202,776...163,216,912
Ensembl chr  X:163,202,783...163,216,912 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 IEA MGI NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 IEA MGI NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482 		JBrowse link
G St14 suppression of tumorigenicity 14 (colon carcinoma) IAGP MGI PMID:24551030 NCBI chr 9:30,999,886...31,043,138
Ensembl chr 9:31,000,698...31,043,149 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:16493008 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IAGP MGI PMID:16493008 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Themis thymocyte selection associated IEA MGI NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IEA MGI NCBI chr 1:36,800,879...36,821,902
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa2 dual oxidase maturation factor 2 IEA MGI NCBI chr 2:122,129,381...122,133,366
Ensembl chr 2:122,129,381...122,133,366 		JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase IEA MGI NCBI chr13:32,003,566...32,522,744
Ensembl chr13:32,003,562...32,522,723 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16210
    hematopoietic system phenotype 5186
      abnormal hematopoietic system morphology/development 4729
        abnormal hematopoietic cell morphology 3959
          abnormal leukocyte morphology 2641
            abnormal leukocyte cell number 2363
              decreased leukocyte cell number 1562
                decreased lymphocyte cell number 1226
                  decreased T cell number 755
                    decreased regulatory T cell number 89
                      absent regulatory T cells 4
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 22
Path 2
Term Annotations click to browse term
  mammalian phenotype 16210
    immune system phenotype 5372
      abnormal immune system morphology 3798
        abnormal immune system cell morphology 2662
          abnormal leukocyte morphology 2641
            abnormal mononuclear cell morphology 2154
              abnormal lymphocyte morphology 1746
                abnormal T cell morphology 1123
                  abnormal regulatory T cell morphology 159
                    abnormal regulatory T cell number 156
                      decreased regulatory T cell number 89
                        absent regulatory T cells 4
                        decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 22
paths to the root