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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:decreased regulatory T cell number
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Accession:MP:0004974 term browser browse the term
Definition:reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
Synonyms:exact_synonym: decreased Treg cell number;   decreased suppressor T cell number;   reduced Treg cell number;   reduced regulatory T cell number



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decreased regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S SHRSP/BbbUtx IAGP compared to SHR/Utx, SHRSP.SHR-(rs197197017-rs198445122)/Utx kidney RGD PMID:32075490 RGD:150429819
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S BBDP.ACI-(D2Arb16-D2Rat63)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:190,602,746...222,436,696 JBrowse link
S BBDP.ACI-(D2Mit8-D2Rat354)/Sunn IAGP compared to BBDP/WorSunn RGD PMID:24920533 RGD:10043114 NCBI chr 2:143,657,411...191,987,650 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5369
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal hematopoietic cell morphology 179
          abnormal leukocyte morphology 147
            abnormal leukocyte cell number 134
              decreased leukocyte cell number 89
                decreased lymphocyte cell number 71
                  decreased T cell number 48
                    decreased regulatory T cell number 3
                      absent regulatory T cells 0
                      decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 5369
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system cell morphology 147
          abnormal leukocyte morphology 147
            abnormal mononuclear cell morphology 120
              abnormal lymphocyte morphology 98
                abnormal T cell morphology 68
                  abnormal regulatory T cell morphology 7
                    abnormal regulatory T cell number 7
                      decreased regulatory T cell number 3
                        absent regulatory T cells 0
                        decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 2
paths to the root