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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased regulatory T cell number
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Accession:MP:0004973 term browser browse the term
Definition:greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
Synonyms:exact_synonym: increased Treg cell number;   increased suppressor T cell number


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increased regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25776069 RGD:13442483
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5374
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal hematopoietic cell morphology 179
          abnormal leukocyte morphology 147
            abnormal leukocyte cell number 134
              increased leukocyte cell number 65
                increased lymphocyte cell number 28
                  increased T cell number 18
                    increased regulatory T cell number 4
                      increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system cell morphology 147
          abnormal leukocyte morphology 147
            abnormal mononuclear cell morphology 120
              abnormal lymphocyte morphology 98
                abnormal T cell morphology 68
                  abnormal regulatory T cell morphology 7
                    abnormal regulatory T cell number 7
                      increased regulatory T cell number 4
                        increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 1
paths to the root