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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal regulatory T cell number
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Accession:MP:0004972 term browser browse the term
Definition:deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
Synonyms:exact_synonym: abnormal Treg cell number;   abnormal suppressor T cell number


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increased regulatory T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25776069 RGD:13442483
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5380
    hematopoietic system phenotype 244
      abnormal hematopoietic system morphology/development 224
        abnormal hematopoietic cell morphology 180
          abnormal hematopoietic cell number 142
            abnormal leukocyte cell number 135
              abnormal lymphocyte cell number 93
                abnormal T cell number 63
                  abnormal regulatory T cell number 7
                    abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 3
                    decreased regulatory T cell number + 3
                    increased regulatory T cell number + 4
Path 2
Term Annotations click to browse term
  mammalian phenotype 5380
    immune system phenotype 495
      abnormal immune system morphology 188
        abnormal immune system cell morphology 148
          abnormal leukocyte morphology 148
            abnormal mononuclear cell morphology 121
              abnormal lymphocyte morphology 99
                abnormal T cell morphology 69
                  abnormal T cell number 63
                    abnormal regulatory T cell number 7
                      abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number + 3
                      decreased regulatory T cell number + 3
                      increased regulatory T cell number + 4
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