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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal class switch recombination
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Accession:MP:0004816 term browser browse the term
Definition:anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
Synonyms:exact_synonym: abnormal CSR;   abnormal isotype switching

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  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune cell physiology 56
          abnormal professional antigen presenting cell physiology 36
            abnormal B cell physiology 31
              abnormal class switch recombination 0
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  mammalian phenotype 5402
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal blood cell morphology 99
            abnormal hemopoiesis 18
              abnormal definitive hematopoiesis 18
                abnormal leukopoiesis 18
                  abnormal lymphopoiesis 18
                    abnormal B cell differentiation 0
                      abnormal class switch recombination 0
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