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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased hematopoietic stem cell number
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Accession:MP:0004809 term browser browse the term
Definition:greater cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages
Synonyms:exact_synonym: increased HSCs;   increased haematopoietic progenitor cell number;   increased haematopoietic stem cell number;   increased haemopoietic progenitor cell number;   increased hematopoietic progenitor cell number;   increased hemopoietic progenitor cell number;   increased number of hematopoietic stem cells
 narrow_synonym: increased LSK cell number
 broad_synonym: Abnormality of blood and blood-forming tissues
 xref: HP:0001871


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increased hematopoietic stem cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 IAGP MGI PMID:22862945 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 IAGP MGI PMID:22862945 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Adam10 a disintegrin and metallopeptidase domain 10 IAGP MGI PMID:22042698 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511 		JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 IAGP MGI PMID:27518564 NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466 		JBrowse link
G Arid1a AT-rich interaction domain 1A IAGP MGI PMID:20522713 NCBI chr 4:133,406,319...133,484,682
Ensembl chr 4:133,406,319...133,484,080 		JBrowse link
G Arid4a AT-rich interaction domain 4A IAGP MGI PMID:18728284 NCBI chr12:71,061,314...71,146,125
Ensembl chr12:71,062,764...71,145,366 		JBrowse link
G Arid4b AT-rich interaction domain 4B IAGP MGI PMID:18728284 NCBI chr13:14,238,334...14,374,188
Ensembl chr13:14,237,817...14,374,188 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 IAGP MGI PMID:29908121 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Asxl1 ASXL transcriptional regulator 1 IAGP MGI PMID:24218140 PMID:24255920 NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927 		JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 IAGP MGI PMID:25636339 NCBI chr 8:71,848,809...71,857,416
Ensembl chr 8:71,849,505...71,857,263 		JBrowse link
G Bap1 Brca1 associated protein 1 IAGP MGI PMID:22878500 NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IAGP MGI PMID:27719760 NCBI chr19:44,127,685...44,134,909
Ensembl chr19:44,127,685...44,134,885 		JBrowse link
G Cbfb core binding factor beta IAGP MGI PMID:12434155 PMID:16413472 NCBI chr 8:105,897,306...105,944,621
Ensembl chr 8:105,897,306...105,944,621 		JBrowse link
G Cbl Casitas B-lineage lymphoma IAGP MGI PMID:19620960 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346 		JBrowse link
G Cdk19 cyclin dependent kinase 19 IAGP MGI PMID:35110726 NCBI chr10:40,225,283...40,359,814
Ensembl chr10:40,215,560...40,359,814 		JBrowse link
G Cdk6 cyclin dependent kinase 6 IAGP MGI PMID:21508411 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A IAGP MGI PMID:10710306 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IAGP MGI PMID:22715416 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Commd10 COMM domain containing 10 IAGP MGI PMID:22422825 PMID:22763442 PMID:30952670 PMID:33753942 NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IAGP MGI PMID:20833981 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Dhx36 DEAH-box helicase 36 IAGP MGI PMID:22422825 NCBI chr 3:62,375,436...62,414,464
Ensembl chr 3:62,375,434...62,414,425 		JBrowse link
G Dnmt3a DNA methyltransferase 3A IAGP MGI PMID:30692594 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443 		JBrowse link
G Dppa3 developmental pluripotency-associated 3 IAGP MGI PMID:26692333 NCBI chr 6:122,603,383...122,607,230
Ensembl chr 6:122,603,369...122,607,231 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 IAGP MGI PMID:16530702 NCBI chr  X:47,499,926...47,552,009
Ensembl chr  X:47,499,923...47,552,009 		JBrowse link
G Etv6 ets variant 6 IAGP MGI PMID:19570513 NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121 		JBrowse link
G Flt3 FMS-like tyrosine kinase 3 IAGP MGI PMID:18245664 NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299 		JBrowse link
G Gfi1 growth factor independent 1 transcription repressor IAGP MGI PMID:22932805 NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902 		JBrowse link
G Gfi1b growth factor independent 1B IAGP MGI PMID:20826720 NCBI chr 2:28,499,462...28,511,994
Ensembl chr 2:28,499,462...28,511,994 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IAGP MGI PMID:20190135 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G Gmnn geminin IAGP MGI PMID:21041951 NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:16980619 PMID:20010698 PMID:20616797 PMID:22606246 PMID:22699452 More... NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit IAGP MGI PMID:22995899 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hip1 huntingtin interacting protein 1 IAGP MGI PMID:19647224 NCBI chr 5:135,435,350...135,574,167
Ensembl chr 5:135,435,385...135,573,974 		JBrowse link
G Hoxa9 homeobox A9 IAGP MGI PMID:17761289 NCBI chr 6:52,200,077...52,203,169
Ensembl chr 6:52,200,080...52,208,069 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble IAGP MGI PMID:22763442 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:25342713 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain IAGP MGI PMID:21508411 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Itga2b integrin alpha 2b IAGP MGI PMID:12871637 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Jak2 Janus kinase 2 IAGP MGI PMID:22144185 PMID:23863895 PMID:26692333 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A IAGP MGI PMID:23795291 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034 		JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A IAGP MGI PMID:29479066 NCBI chr  X:18,027,101...18,147,061
Ensembl chr  X:18,028,814...18,146,175 		JBrowse link
G Kmt2e lysine (K)-specific methyltransferase 2E IAGP MGI PMID:18818388 NCBI chr 5:23,638,034...23,709,233
Ensembl chr 5:23,639,439...23,709,233 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:25359213 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Lyz2 lysozyme 2 IAGP MGI PMID:22763442 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Man2a1 mannosidase 2, alpha 1 IAGP MGI PMID:9230311 NCBI chr17:64,907,683...65,062,105
Ensembl chr17:64,907,731...65,062,105 		JBrowse link
G Matk megakaryocyte-associated tyrosine kinase IAGP MGI PMID:16574955 NCBI chr10:81,088,769...81,098,819
Ensembl chr10:81,088,769...81,099,199 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 IAGP MGI PMID:26456157 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536 		JBrowse link
G Meis1 Meis homeobox 1 IAGP MGI PMID:22995899 NCBI chr11:18,830,428...18,968,992
Ensembl chr11:18,829,817...18,968,985 		JBrowse link
G Meox2 mesenchyme homeobox 2 IAGP MGI PMID:33681212 NCBI chr12:37,158,539...37,229,533
Ensembl chr12:37,158,539...37,229,533 		JBrowse link
G Ncstn nicastrin IAGP MGI PMID:21562564 NCBI chr 1:171,893,580...171,910,356
Ensembl chr 1:171,893,580...171,910,362 		JBrowse link
G Npm1 nucleophosmin 1 IAGP MGI PMID:21979879 PMID:23226219 NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 IAGP MGI PMID:17515897 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 IAGP MGI PMID:17515897 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447 		JBrowse link
G Nras neuroblastoma ras oncogene IAGP MGI PMID:33681212 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Ociad1 OCIA domain containing 1 IAGP MGI PMID:30952670 NCBI chr 5:73,450,093...73,471,420
Ensembl chr 5:73,450,127...73,471,412 		JBrowse link
G Pclaf PCNA clamp associated factor IAGP MGI PMID:21844206 NCBI chr 9:65,797,605...65,810,833
Ensembl chr 9:65,797,519...65,810,548 		JBrowse link
G Per2 period circadian clock 2 IAGP MGI PMID:23193187 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pfkm phosphofructokinase, muscle IAGP MGI PMID:19696889 NCBI chr15:97,990,470...98,030,328
Ensembl chr15:97,990,470...98,030,332 		JBrowse link
G Phf6 PHD finger protein 6 IAGP MGI PMID:30755422 PMID:31395598 NCBI chr  X:52,001,091...52,045,838
Ensembl chr  X:52,001,143...52,045,820 		JBrowse link
G Pml promyelocytic leukemia IAGP MGI PMID:29191918 NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069 		JBrowse link
G Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) IAGP MGI PMID:29754823 NCBI chr 6:82,593,513...82,629,985
Ensembl chr 6:82,595,973...82,682,346 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform IAGP MGI PMID:21514445 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 IAGP MGI PMID:23290137 NCBI chr 2:90,741,057...90,748,395
Ensembl chr 2:90,739,060...90,748,389 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IAGP MGI PMID:21930766 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Rbm15 RNA binding motif protein 15 IAGP MGI PMID:17376872 PMID:19287095 PMID:19542301 NCBI chr 3:107,212,827...107,244,102
Ensembl chr 3:107,232,737...107,240,989 		JBrowse link
G Riok2 RIO kinase 2 IAGP MGI PMID:33753942 NCBI chr17:17,594,594...17,615,161
Ensembl chr17:17,594,571...17,615,161 		JBrowse link
G Runx1 runt related transcription factor 1 IAGP MGI PMID:16247465 PMID:19129762 PMID:19570513 PMID:19647224 PMID:20139099 More... NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Scmh1 sex comb on midleg homolog 1 IAGP MGI PMID:23207902 NCBI chr 4:120,262,347...120,387,397
Ensembl chr 4:120,262,478...120,387,383 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 IAGP MGI PMID:27622333 NCBI chr 1:55,024,328...55,066,660
Ensembl chr 1:55,024,328...55,066,640 		JBrowse link
G Sipa1 signal-induced proliferation associated gene 1 IAGP MGI PMID:12892713 NCBI chr19:5,701,211...5,713,758
Ensembl chr19:5,701,213...5,713,735 		JBrowse link
G Spi1 Spi-1 proto-oncogene IAGP MGI PMID:23395001 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Spp1 secreted phosphoprotein 1 IAGP MGI PMID:15845900 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 IAGP MGI PMID:25965569 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920 		JBrowse link
G Stag2 STAG2 cohesin complex component IAGP MGI PMID:32249213 NCBI chr  X:41,238,172...41,366,063
Ensembl chr  X:41,238,194...41,366,062 		JBrowse link
G Stk11 serine/threonine kinase 11 IAGP MGI PMID:21124450 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Tal1 T cell acute lymphocytic leukemia 1 IAGP MGI PMID:22401818 NCBI chr 4:114,913,623...114,928,952
Ensembl chr 4:114,913,623...114,928,952 		JBrowse link
G Tcim transcriptional and immune response regulator IAGP MGI PMID:24937306 NCBI chr 8:24,927,188...24,928,962
Ensembl chr 8:24,927,196...24,929,000 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 IAGP MGI PMID:21723201 PMID:21803851 PMID:21873190 PMID:27622333 NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:21844206 PMID:23538418 PMID:29479066 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor IAGP MGI PMID:22464323 NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594 		JBrowse link
G Wbp1l WW domain binding protein 1 like IAGP MGI PMID:31845480 NCBI chr19:46,587,545...46,645,828
Ensembl chr19:46,587,523...46,645,828 		JBrowse link
G Xist inactive X specific transcripts IAGP MGI PMID:16980619 NCBI chr  X:102,503,979...102,526,839
Ensembl chr  X:102,503,972...102,537,573 		JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a IAGP MGI PMID:17495164 NCBI chr10:80,971,113...80,988,056
Ensembl chr10:80,971,054...80,988,829 		JBrowse link
G Zfand2b zinc finger, AN1 type domain 2B IAGP MGI PMID:26692333 NCBI chr 1:75,145,290...75,148,270
Ensembl chr 1:75,145,290...75,148,273 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17059
    hematopoietic system phenotype 5601
      abnormal hematopoietic system morphology/development 5127
        abnormal hematopoietic cell morphology 4304
          abnormal hematopoietic cell number 3113
            increased hematopoietic cell number 2079
              increased hematopoietic stem cell number 84
paths to the root