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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal circulating insulin-like growth factor I level
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Accession:MP:0004700 term browser browse the term
Definition:anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities
Synonyms:exact_synonym: abnormal circulating IGF-I level;   abnormal circulating IGF1 level


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abnormal circulating insulin-like growth factor I level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npy6r neuropeptide Y receptor Y6 IAGP MGI PMID:24411939 NCBI chr18:44,403,175...44,410,767
Ensembl chr18:44,403,194...44,410,767 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IAGP MGI PMID:14673173 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
decreased circulating insulin-like growth factor I level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 IAGP MGI PMID:28973305 NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423 		JBrowse link
G Arid1b AT-rich interaction domain 1B IAGP MGI PMID:28695822 NCBI chr17:5,044,481...5,397,931
Ensembl chr17:5,044,607...5,397,931 		JBrowse link
G Cdo1 cysteine dioxygenase 1, cytosolic IAGP MGI PMID:21693692 NCBI chr18:46,846,260...46,861,569
Ensembl chr18:46,846,260...46,861,462 		JBrowse link
G Col6a1 collagen, type VI, alpha 1 IAGP MGI PMID:28043812 NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002 		JBrowse link
G Drd2 dopamine receptor D2 IAGP MGI PMID:11897683 PMID:23536095 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Duox2 dual oxidase 2 IAGP MGI PMID:17440044 NCBI chr 2:122,109,727...122,129,221
Ensembl chr 2:122,109,728...122,128,930 		JBrowse link
G E2f1 E2F transcription factor 1 IAGP MGI PMID:18594513 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G E2f3 E2F transcription factor 3 IAGP MGI PMID:18594513 NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 IAGP MGI PMID:17183314 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) IAGP MGI PMID:10558910 PMID:10805804 PMID:16234973 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) IAGP MGI PMID:10805804 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fgf21 fibroblast growth factor 21 IAGP MGI PMID:22374976 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Foxl2 forkhead box L2 IAGP MGI PMID:15056605 NCBI chr 9:98,837,495...98,840,601
Ensembl chr 9:98,837,341...98,840,596 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase IAGP MGI PMID:21103374 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Galc galactosylceramidase IAGP MGI PMID:20441793 NCBI chr12:98,168,543...98,226,565
Ensembl chr12:98,168,553...98,225,718 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IAGP MGI PMID:11089562 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Ghr growth hormone receptor IAGP MGI PMID:9371826 PMID:10067829 PMID:10631109 PMID:10875265 PMID:11133160 More... NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Ghrh growth hormone releasing hormone IAGP MGI PMID:15155578 NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor IAGP MGI PMID:15388648 NCBI chr 6:55,353,204...55,365,515
Ensembl chr 6:55,353,280...55,365,515 		JBrowse link
G Ghsr growth hormone secretagogue receptor IAGP MGI PMID:15070777 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IAGP MGI PMID:18845638 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:21283519 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Gulo gulonolactone (L-) oxidase IAGP MGI PMID:11062347 NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656 		JBrowse link
G Hnf1a HNF1 homeobox A IAGP MGI PMID:9566924 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C IAGP MGI PMID:19036977 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Igf1 insulin-like growth factor 1 IAGP MGI PMID:10359843 PMID:17535874 PMID:19033454 PMID:20048072 PMID:20382057 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IAGP MGI PMID:16675541 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 IAGP MGI PMID:16675541 NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 IAGP MGI PMID:16675541 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043 		JBrowse link
G Itprid2 ITPR interacting domain containing 2 IAGP MGI PMID:19156225 NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310 		JBrowse link
G Kdm3b KDM3B lysine (K)-specific demethylase 3B IAGP MGI PMID:25892958 NCBI chr18:34,910,061...34,972,423
Ensembl chr18:34,910,100...34,971,713 		JBrowse link
G Lhx3 LIM homeobox protein 3 IAGP MGI PMID:21149718 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IAGP MGI PMID:20231445 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mark2 MAP/microtubule affinity regulating kinase 2 IAGP MGI PMID:17372192 NCBI chr19:7,252,761...7,319,222
Ensembl chr19:7,252,761...7,319,225 		JBrowse link
G Mbd5 methyl-CpG binding domain protein 5 IAGP MGI PMID:23077600 NCBI chr 2:48,839,511...49,209,702
Ensembl chr 2:48,839,520...49,215,417 		JBrowse link
G Mex3c mex3 RNA binding family member C IAGP MGI PMID:22357625 NCBI chr18:73,705,710...73,725,649
Ensembl chr18:73,706,115...73,725,646 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IAGP MGI PMID:20388826 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myf5 myogenic factor 5 IAGP MGI PMID:17158201 NCBI chr10:107,318,769...107,322,787
Ensembl chr10:107,318,769...107,321,995 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 IAGP MGI PMID:10823921 PMID:11087842 PMID:18690289 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162 		JBrowse link
G Npy6r neuropeptide Y receptor Y6 IAGP MGI PMID:24411939 NCBI chr18:44,403,175...44,410,767
Ensembl chr18:44,403,194...44,410,767 		JBrowse link
G Opa3 optic atrophy 3 IAGP MGI PMID:22869679 NCBI chr 7:18,962,314...18,980,742
Ensembl chr 7:18,962,259...18,990,468 		JBrowse link
G Pdia6 protein disulfide isomerase associated 6 IAGP MGI PMID:31985756 NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771 		JBrowse link
G Pdyn prodynorphin IAGP MGI PMID:17456788 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Phf6 PHD finger protein 6 IAGP MGI PMID:32994169 NCBI chr  X:52,001,091...52,045,838
Ensembl chr  X:52,001,143...52,045,820 		JBrowse link
G Pmm2 phosphomannomutase 2 IAGP MGI PMID:27053713 NCBI chr16:8,455,467...8,475,472
Ensembl chr16:8,455,538...8,480,331 		JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 IAGP MGI PMID:36719796 NCBI chr 2:24,865,235...24,944,084
Ensembl chr 2:24,866,045...24,944,069 		JBrowse link
G Prlr prolactin receptor IAGP MGI PMID:15388648 NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266 		JBrowse link
G Ptch1 patched 1 IAGP MGI PMID:23404854 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 IAGP MGI PMID:22000926 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S IAGP MGI PMID:10080191 NCBI chr17:56,719,426...56,783,480
Ensembl chr17:56,719,426...56,783,483 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 IAGP MGI PMID:9603515 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030 		JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 IAGP MGI PMID:20674857 NCBI chr15:39,061,681...39,547,768
Ensembl chr15:39,061,656...39,547,768 		JBrowse link
G Safb scaffold attachment factor B IAGP MGI PMID:15798188 NCBI chr17:56,891,982...56,913,294
Ensembl chr17:56,891,825...56,913,294 		JBrowse link
G Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha IAGP MGI PMID:27358191 NCBI chr10:80,879,905...80,896,105
Ensembl chr10:80,879,909...80,896,015 		JBrowse link
G Sirt1 sirtuin 1 IAGP MGI PMID:20008932 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt6 sirtuin 6 IAGP MGI PMID:16439206 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 IAGP MGI PMID:14578452 NCBI chr 6:24,088,282...24,168,118
Ensembl chr 6:24,088,282...24,168,091 		JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 IAGP MGI PMID:21445361 NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral IAGP MGI PMID:15764706 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IAGP MGI PMID:22562833 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:19460757 PMID:23299886 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
G Spr sepiapterin reductase IAGP MGI PMID:16532389 NCBI chr 6:85,110,662...85,114,746
Ensembl chr 6:85,107,158...85,114,748 		JBrowse link
G Srsf3 serine and arginine-rich splicing factor 3 IAGP MGI PMID:23299886 NCBI chr17:29,251,634...29,262,346
Ensembl chr17:29,251,602...29,262,347 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:17158201 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IAGP MGI PMID:9207075 PMID:17158201 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Suco SUN domain containing ossification factor IAGP MGI PMID:20440000 NCBI chr 1:161,643,681...161,704,506
Ensembl chr 1:161,643,683...161,704,251 		JBrowse link
G Thra thyroid hormone receptor alpha IAGP MGI PMID:11731613 PMID:17327419 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta IAGP MGI PMID:17327419 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tmem263 transmembrane protein 263 IAGP MGI PMID:38241182 NCBI chr10:84,938,491...84,953,611
Ensembl chr10:84,938,491...84,956,482 		JBrowse link
G Tph2 tryptophan hydroxylase 2 IAGP MGI PMID:19520831 NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:17996864 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tut4 terminal uridylyl transferase 4 IAGP MGI PMID:23209448 NCBI chr 4:108,316,607...108,416,612
Ensembl chr 4:108,316,623...108,416,618 		JBrowse link
G Zmpste24 zinc metallopeptidase, STE24 IAGP MGI PMID:20805469 NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438 		JBrowse link
increased circulating insulin-like growth factor I level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) IAGP MGI PMID:32488095 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 IAGP MGI PMID:29661920 NCBI chr 2:5,901,030...5,947,648
Ensembl chr 2:5,900,926...5,947,603 		JBrowse link
G Esr2 estrogen receptor 2 (beta) IAGP MGI PMID:11380688 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Ghr growth hormone receptor IAGP MGI PMID:23349524 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Igf1 insulin-like growth factor 1 IAGP MGI PMID:14741342 PMID:19497975 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il1r1 interleukin 1 receptor, type I IAGP MGI PMID:16644674 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Lif leukemia inhibitory factor IAGP MGI PMID:14741342 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 IAGP MGI PMID:20534466 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,545...165,915,162 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 IAGP MGI PMID:17272395 NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391 		JBrowse link
G Npy4r neuropeptide Y receptor Y4 IAGP MGI PMID:17272395 NCBI chr14:33,867,603...33,874,376
Ensembl chr14:33,865,949...33,874,446 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IAGP MGI PMID:26974159 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pyy peptide YY IAGP MGI PMID:16680491 NCBI chr11:101,997,502...101,998,658
Ensembl chr11:101,997,502...101,998,658 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 IAGP MGI PMID:19497867 NCBI chr15:6,737,827...6,829,882
Ensembl chr15:6,737,860...6,829,882 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein IAGP MGI PMID:19293327 NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16965
    homeostasis/metabolism phenotype 7867
      abnormal homeostasis 7017
        abnormal hormone level 1306
          abnormal circulating hormone level 1168
            abnormal circulating insulin-like growth factor I level 102
              decreased circulating insulin-like growth factor I level 79
              increased circulating insulin-like growth factor I level 29
paths to the root