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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased susceptibility to ototoxicity-induced hearing loss
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Accession:MP:0004611 term browser browse the term
Definition:greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process
Synonyms:exact_synonym: decreased resistance to ototoxicity-induced hearing loss


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increased susceptibility to ototoxicity-induced hearing loss term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A IAGP MGI PMID:10661503 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 IAGP MGI PMID:15862894 NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16478
    homeostasis/metabolism phenotype 7551
      abnormal physiological response to xenobiotic 768
        increased physiological sensitivity to xenobiotic 343
          increased susceptibility to ototoxicity-induced hearing loss 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 16478
    hearing/vestibular/ear phenotype 992
      abnormal ear physiology 711
        abnormal hearing physiology 658
          abnormal susceptibility to hearing loss 48
            increased susceptibility to ototoxicity-induced hearing loss 2
paths to the root