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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased heart rate variability
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Accession:MP:0003928 term browser browse the term
Definition:increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle
Comment:Heart rate variability (HRV) is the variation of beat-to-beat intervals. A healthy heart has a large HRV, while decreased or absent variability may indicate cardiac disease. HRV also decreases with exercise-induced tachycardia. Heart rate variability (HRV) refers to the beat-to-beat alterations in heart rate. Under resting conditions, the ECG of healthy individuals exhibits periodic variation in R-R intervals. This rhythmic phenomenon, known as respiratory sinus arrhythmia (RSA), fluctuates with the phase of respiration -- cardio-acceleration during inspiration, and cardio-deceleration during expiration. RSA is predominantly mediated by respiratory gating of parasympathetic efferent activity to the heart: vagal efferent traffic to the sinus node occurs primarily in phase with expiration and is absent or attenuated during inspiration. The major reason for the interest in measuring HRV stems from its ability to predict survival after heart attack. Over half a dozen prospective studies have shown that reduced HRV predicts sudden death in patients with MI, independent of other prognostic indicators such as ejection fraction. Reduced HRV appears to be a marker of fatal ventricular arrhythmia. Moreover, a small number of studies have begun to suggest that reduced HRV may predict risk of survival even among individuals free of CHD.
Synonyms:exact_synonym: increased HRV;   increased heart rate variation;   increased respiratory sinus arrhythmia


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increased heart rate variability term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
Q Hrtrt13 Heart rate QTL 13 IAGP RGD PMID:11721057 RGD:70849 NCBI chr 4:110,275,411...168,266,883 JBrowse link
Q Hrtrt14 Heart rate QTL 14 IAGP RGD PMID:11721057 RGD:70849 NCBI chr12:9,318,216...12,829,686 JBrowse link
Q Hrtrt15 Heart rate QTL 15 IAGP RGD PMID:11721057 RGD:70849 NCBI chr17:15,330,613...55,836,425 JBrowse link
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  mammalian phenotype 5373
    cardiovascular system phenotype 1356
      abnormal cardiovascular system physiology 1132
        abnormal heartbeat 69
          abnormal heart rate 69
            abnormal sinus arrhythmia 3
              increased heart rate variability 3
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