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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal circulating ketone body level
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Accession:MP:0003457 term browser browse the term
Definition:aberrant amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
Comment:Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in equilibrium with acetoacetate.



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abnormal circulating ketone body level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gys2 glycogen synthase 2 IAGP MGI PMID:20178984 NCBI chr 6:142,368,338...142,418,856
Ensembl chr 6:142,368,339...142,418,835
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 IAGP MGI PMID:35421611 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
JBrowse link
G Klb klotho beta IAGP MGI PMID:23209629 NCBI chr 5:65,505,754...65,544,300
Ensembl chr 5:65,505,657...65,541,350
JBrowse link
G Plin1 perilipin 1 IAGP MGI PMID:11101849 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IAGP MGI PMID:10377439 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:20178984 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317
JBrowse link
decreased circulating ketone body level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor IAGP MGI PMID:31597092 NCBI chr19:31,846,156...31,929,765
Ensembl chr19:31,846,164...31,926,395
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha IAGP MGI PMID:16717184 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acot13 acyl-CoA thioesterase 13 IAGP MGI PMID:22345407 NCBI chr13:25,001,938...25,015,472
Ensembl chr13:25,001,931...25,015,523
JBrowse link
G Agrp agouti related neuropeptide IAGP MGI PMID:23864684 NCBI chr 8:106,293,327...106,306,477
Ensembl chr 8:106,293,330...106,364,025
JBrowse link
G Aqp11 aquaporin 11 IAGP MGI PMID:23275615 NCBI chr 7:97,375,586...97,387,454
Ensembl chr 7:97,373,213...97,387,496
JBrowse link
G Bcat2 branched chain aminotransferase 2, mitochondrial IAGP MGI PMID:17767905 NCBI chr 7:45,218,391...45,239,134
Ensembl chr 7:45,219,577...45,239,135
JBrowse link
G Cidec cell death-inducing DFFA-like effector c IAGP MGI PMID:18682832 NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721
JBrowse link
G Fgf21 fibroblast growth factor 21 IAGP MGI PMID:19541642 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914
JBrowse link
G Hadh hydroxyacyl-Coenzyme A dehydrogenase IAGP MGI PMID:21990309 NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 IAGP MGI PMID:35421611 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
JBrowse link
G Mgll monoglyceride lipase IAGP MGI PMID:21454566 NCBI chr 6:88,701,381...88,805,342
Ensembl chr 6:88,701,394...88,805,342
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic IAGP MGI PMID:11792850 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Rubcnl RUN and cysteine rich domain containing beclin 1 interacting protein like IAGP MGI PMID:30704899 NCBI chr14:75,253,467...75,289,977
Ensembl chr14:75,253,467...75,289,972
JBrowse link
G Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 IAGP MGI PMID:16618416 NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 IAGP MGI PMID:7675081 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 IAGP MGI PMID:25141153 NCBI chr 1:4,561,151...4,567,624
Ensembl chr 1:4,561,154...4,567,577
JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:16717184 PMID:23275615 PMID:30704899 PMID:31597092 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317
JBrowse link
G Tsc1 TSC complex subunit 1 IAGP MGI PMID:21179166 NCBI chr 2:28,531,005...28,581,184
Ensembl chr 2:28,531,240...28,581,179
JBrowse link
increased circulating ketone body level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-Coenzyme A carboxylase beta IAGP MGI PMID:11283375 NCBI chr 5:114,284,378...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Actb actin, beta IAGP MGI PMID:15254588 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 IAGP MGI PMID:11579206 NCBI chr17:93,505,673...93,513,969
Ensembl chr17:93,506,445...93,513,965
JBrowse link
G Apoc3 apolipoprotein C-III IAGP MGI PMID:15734841 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934
JBrowse link
G Arrdc3 arrestin domain containing 3 IAGP MGI PMID:21982743 NCBI chr13:81,031,503...81,044,161
Ensembl chr13:81,031,503...81,044,161
JBrowse link
G Bag3 BCL2-associated athanogene 3 IAGP MGI PMID:18840758 NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705
JBrowse link
G Cd36 CD36 molecule IAGP MGI PMID:12923231 PMID:17440173 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cltrn collectrin, amino acid transport regulator IAGP MGI PMID:19246514 NCBI chr  X:162,873,183...162,901,855
Ensembl chr  X:162,871,826...162,901,856
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like IAGP MGI PMID:30926667 NCBI chr 5:96,218,192...96,312,044
Ensembl chr 5:96,218,192...96,312,030
JBrowse link
G Edn2 endothelin 2 IAGP MGI PMID:23676500 NCBI chr 4:120,018,403...120,024,557
Ensembl chr 4:120,018,403...120,024,557
JBrowse link
G Epm2a epilepsy, progressive myoclonic epilepsy, type 2 gene alpha IAGP MGI PMID:21493628 NCBI chr10:11,218,435...11,335,408
Ensembl chr10:11,219,148...11,335,388
JBrowse link
G Ffar3 free fatty acid receptor 3 IAGP MGI PMID:21518883 NCBI chr 7:30,553,755...30,555,603
Ensembl chr 7:30,553,755...30,555,603
JBrowse link
G Fgf21 fibroblast growth factor 21 IAGP MGI PMID:19589869 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914
JBrowse link
G Glis3 GLIS family zinc finger 3 IAGP MGI PMID:21786021 NCBI chr19:28,236,251...28,657,684
Ensembl chr19:28,236,251...28,657,477
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial IAGP MGI PMID:18339309 NCBI chr19:55,056,067...55,115,751
Ensembl chr19:55,055,700...55,115,670
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha IAGP MGI PMID:16498401 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
JBrowse link
G Ins2 insulin II IAGP MGI PMID:15587270 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Insr insulin receptor IAGP MGI PMID:15254588 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Klf15 Kruppel-like factor 15 IAGP MGI PMID:17403374 NCBI chr 6:90,437,785...90,468,785
Ensembl chr 6:90,439,558...90,452,220
JBrowse link
G Lepr leptin receptor IAGP MGI PMID:22118645 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lipa lysosomal acid lipase A IAGP MGI PMID:30639734 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874
JBrowse link
G Lmna lamin A IAGP MGI PMID:21818413 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Mcat malonyl CoA:ACP acyltransferase (mitochondrial) IAGP MGI PMID:23077570 NCBI chr15:83,430,998...83,439,956
Ensembl chr15:83,430,998...83,447,988
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 IAGP MGI PMID:26344103 NCBI chr17:8,502,590...8,516,499
Ensembl chr17:8,501,736...8,516,493
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 IAGP MGI PMID:24910426 NCBI chr 1:165,288,829...165,308,787
Ensembl chr 1:165,288,206...165,308,783
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IAGP MGI PMID:19037247 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 IAGP MGI PMID:21209089 NCBI chr15:4,055,910...4,184,826
Ensembl chr15:4,055,865...4,184,826
JBrowse link
G Pank1 pantothenate kinase 1 IAGP MGI PMID:22815849 NCBI chr19:34,784,335...34,862,420
Ensembl chr19:34,784,340...34,856,855
JBrowse link
G Pank2 pantothenate kinase 2 IAGP MGI PMID:22815849 NCBI chr 2:131,103,928...131,141,108
Ensembl chr 2:131,104,415...131,141,108
JBrowse link
G Pax6 paired box 6 IAGP MGI PMID:15110714 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic IAGP MGI PMID:16300682 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pcx pyruvate carboxylase IAGP MGI PMID:36441025 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 IAGP MGI PMID:33773101 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 IAGP MGI PMID:33773101 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 IAGP MGI PMID:33773101 NCBI chr  X:92,798,923...92,875,756
Ensembl chr  X:92,808,213...92,875,807
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 IAGP MGI PMID:16606348 PMID:33773101 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha IAGP MGI PMID:23169785 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879
JBrowse link
G Phkb phosphorylase kinase beta IAGP MGI PMID:36077341 NCBI chr 8:86,567,489...86,790,880
Ensembl chr 8:86,567,588...86,788,005
JBrowse link
G Pygl liver glycogen phosphorylase IAGP MGI PMID:31701076 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262
JBrowse link
G Rgs16 regulator of G-protein signaling 16 IAGP MGI PMID:21357625 NCBI chr 1:153,616,099...153,621,214
Ensembl chr 1:153,616,095...153,621,214
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 IAGP MGI PMID:21179166 NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 IAGP MGI PMID:12177411 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 IAGP MGI PMID:26596471 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial IAGP MGI PMID:7493016 PMID:11677043 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:21179166 PMID:26344103 PMID:30639734 PMID:36441025 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 IAGP MGI PMID:19564420 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase IAGP MGI PMID:19651815 NCBI chr 8:35,296,333...35,432,844
Ensembl chr 8:35,293,614...35,432,844
JBrowse link
G Txnip thioredoxin interacting protein IAGP MGI PMID:16254043 PMID:18322014 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 IAGP MGI PMID:19273596 NCBI chr16:42,728,008...43,462,442
Ensembl chr16:42,696,244...43,462,965
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16210
    homeostasis/metabolism phenotype 7344
      abnormal homeostasis 6518
        abnormal blood homeostasis 5005
          abnormal circulating ketone body level 68
            decreased circulating ketone body level 18
            increased circulating ketone body level 49
paths to the root