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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:amyloid beta deposits
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Accession:MP:0003329 term browser browse the term
Definition:formation of self-assembled aggregates of the cleaved App Abeta protein fragment; often seen in neurodegenerative disorders such as Alzheimer's disease
Synonyms:exact_synonym: amyloid beta plaques;   increased amyloid beta deposition
 narrow_synonym: Alzheimer's disease neuropathologic change
 broad_synonym: Senile plaques
 related_synonym: Alzheimer disease
 xref: EFO:0006801;   HP:0002511;   HP:0100256


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amyloid beta deposits term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S F344-Tg(APP)21Besey IMP induced by human Alzheimer brain extracts containing aggregated Abeta RGD PMID:22017494 RGD:7247288
S OXYS/Nov IAGP RGD PMID:24047616 RGD:13503332
S SD-Tg(UbC-APPswe)6590 IMP human transgene in a rat model RGD PMID:17506994 RGD:2290385
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  mammalian phenotype 5440
    nervous system phenotype 386
      abnormal nervous system morphology 222
        nervous system inclusion bodies 10
          amyloid beta deposits 3
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