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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:neuron degeneration
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Accession:MP:0003224 term browser browse the term
Definition:a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses


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retina photoreceptor degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myo15a myosin XVA induces IAGP DNA:missense mutation:cds:exon 56 T>C, p.Leu3157Pro (rat)
compared to LEW/Ztm 		RGD PMID:21479269 PMID:21479269 RGD:150429616, RGD:150429616 NCBI chr10:45,277,619...45,335,953
Ensembl chr10:45,278,737...45,335,340 		JBrowse link
G Myo15aci2 myosin XVA; ci2 mutant induces IAGP compared to LEW/Ztm RGD PMID:21479269 RGD:150429616
G Pde6b phosphodiesterase 6B IMP compared to wild-type RGD PMID:31009522 RGD:40924664 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450 		JBrowse link
G Pde6bem1Baek phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek IMP compared to wild-type RGD PMID:31009522 RGD:40924664
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  mammalian phenotype 5428
    nervous system phenotype 383
      abnormal nervous system morphology 220
        abnormal neuron morphology 74
          neuron degeneration 17
            Purkinje cell degeneration + 0
            amacrine cell degeneration 0
            cochlear hair cell degeneration + 0
            hippocampal neuron degeneration 0
            motor neuron degeneration 7
            retina ganglion cell degeneration 0
            retina photoreceptor degeneration + 8
            vestibular hair cell degeneration 0
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