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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased insulin secretion
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Accession:MP:0003059 term browser browse the term
Definition:reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
Synonyms:exact_synonym: reduced insulin secretion


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decreased insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IMP compared to wild type RGD PMID:30616503 RGD:150573710 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcc8em1Cgen ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen IMP compared to wild type RGD PMID:30616503 RGD:150573710
G Tbc1d1 TBC1 domain family member 1 induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499 		JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607
G Wfs1 wolframin ER transmembrane glycoprotein induces IMP RGD PMID:29976929 RGD:150519890 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Wfs1em1Ptsn wolframin ER transmembrane glycoprotein; ZFN induced mutant 1 induces IMP RGD PMID:29976929 RGD:150519890
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5418
    homeostasis/metabolism phenotype 1423
      abnormal homeostasis 1324
        abnormal glucose homeostasis 355
          abnormal insulin secretion 26
            decreased insulin secretion 17
Path 2
Term Annotations click to browse term
  mammalian phenotype 5418
    endocrine/exocrine gland phenotype 394
      abnormal gland physiology 85
        abnormal pancreas physiology 67
          abnormal endocrine pancreas physiology 28
            abnormal pancreatic beta cell physiology 27
              abnormal insulin secretion 26
                decreased insulin secretion 17
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