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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:impaired skin barrier function
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Accession:MP:0002796 term browser browse the term
Definition:impaired ability of the skin to regulate water loss; frequently leads to dehydration
Synonyms:related_synonym: increased TEWL;   increased TWL;   increased trans-epidermal water loss;   increased transepidermal water loss

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impaired skin barrier function term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S KFRS4/Kyo sexual_dimorphism IAGP compared to control PVG/Seac rats; more frequent in females RGD PMID:26454563 RGD:150429840

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    integument phenotype 171
      abnormal skin physiology 1
        impaired skin barrier function 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    homeostasis/metabolism phenotype 1418
      abnormal homeostasis 1319
        abnormal fluid regulation 102
          impaired skin barrier function 1
paths to the root