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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal Leydig cell morphology
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Accession:MP:0002786 term browser browse the term
Definition:any structural anomaly of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH); Leydig cells are polyhedral in shape, display a large prominent nucleus, an eosinophilic cytoplasm and numerous lipid-filled vesicles
Synonyms:exact_synonym: abnormal Leydig cells



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abnormal Leydig cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wwox WW domain-containing oxidoreductase IAGP DNA:deletion:cds:exon 9, 13bp nucleotides 1190-1202
compared to wild type and heterozygotes
RGD PMID:19500159 PMID:17803050 PMID:18676360 RGD:150429979, RGD:150429978, RGD:150429974 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 PMID:19500159 PMID:17803050 RGD:150429974, RGD:150429979, RGD:150429978
abnormal adult Leydig cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhh desert hedgehog signaling molecule IMP RGD PMID:21062903 RGD:38548923 NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
JBrowse link
abnormal fetal Leydig cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhh desert hedgehog signaling molecule IMP RGD PMID:21062903 RGD:38548923 NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5369
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal sex gland morphology 67
          abnormal male reproductive gland morphology 58
            abnormal testis morphology 46
              abnormal testis interstitial tissue morphology 5
                abnormal Leydig cell morphology 5
                  Leydig cell atrophy 0
                  Leydig cell hypertrophy 0
                  abnormal Leydig cell differentiation + 2
                  decreased Leydig cell number + 0
                  ectopic Leydig cells 0
                  increased Leydig cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5369
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal male reproductive system morphology 66
          abnormal male genitalia morphology 66
            abnormal internal male genitalia morphology 58
              abnormal testis morphology 46
                abnormal testis interstitial tissue morphology 5
                  abnormal Leydig cell morphology 5
                    Leydig cell atrophy 0
                    Leydig cell hypertrophy 0
                    abnormal Leydig cell differentiation + 2
                    decreased Leydig cell number + 0
                    ectopic Leydig cells 0
                    increased Leydig cell number 0
paths to the root