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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased circulating ketone body level
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Accession:MP:0002575 term browser browse the term
Definition:greater than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
Comment:Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in equilibrium with acetoacetate.
Synonyms:exact_synonym: elevated circulating ketone body level;   hyperketonaemia;   hyperketonemia
 narrow_synonym: elevated plasma ketone body level;   elevated serum ketone body level


show annotations for term's descendants           Sort by:
increased circulating ketone body level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-Coenzyme A carboxylase beta IAGP MGI PMID:11283375 NCBI chr 5:114,284,378...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Actb actin, beta IAGP MGI PMID:15254588 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 IAGP MGI PMID:11579206 NCBI chr17:93,505,673...93,513,969
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Apoc3 apolipoprotein C-III IAGP MGI PMID:15734841 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Arrdc3 arrestin domain containing 3 IAGP MGI PMID:21982743 NCBI chr13:81,031,503...81,044,161
Ensembl chr13:81,031,503...81,044,161 		JBrowse link
G Bag3 BCL2-associated athanogene 3 IAGP MGI PMID:18840758 NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705 		JBrowse link
G Cd36 CD36 molecule IAGP MGI PMID:12923231 PMID:17440173 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cltrn collectrin, amino acid transport regulator IAGP MGI PMID:19246514 NCBI chr  X:162,873,183...162,901,855
Ensembl chr  X:162,871,826...162,901,856 		JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like IAGP MGI PMID:30926667 NCBI chr 5:96,218,192...96,312,044
Ensembl chr 5:96,218,192...96,312,030 		JBrowse link
G Edn2 endothelin 2 IAGP MGI PMID:23676500 NCBI chr 4:120,018,403...120,024,557
Ensembl chr 4:120,018,403...120,024,557 		JBrowse link
G Epm2a epilepsy, progressive myoclonic epilepsy, type 2 gene alpha IAGP MGI PMID:21493628 NCBI chr10:11,218,435...11,335,408
Ensembl chr10:11,219,148...11,335,388 		JBrowse link
G Ffar3 free fatty acid receptor 3 IAGP MGI PMID:21518883 NCBI chr 7:30,553,755...30,555,603
Ensembl chr 7:30,553,755...30,555,603 		JBrowse link
G Fgf21 fibroblast growth factor 21 IAGP MGI PMID:19589869 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Glis3 GLIS family zinc finger 3 IAGP MGI PMID:21786021 NCBI chr19:28,236,251...28,657,684
Ensembl chr19:28,236,251...28,657,477 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial IAGP MGI PMID:18339309 NCBI chr19:55,056,067...55,115,751
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha IAGP MGI PMID:16498401 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830 		JBrowse link
G Ins2 insulin II IAGP MGI PMID:15587270 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insr insulin receptor IAGP MGI PMID:15254588 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Klf15 Kruppel-like factor 15 IAGP MGI PMID:17403374 NCBI chr 6:90,437,785...90,468,785
Ensembl chr 6:90,439,558...90,452,220 		JBrowse link
G Lepr leptin receptor IAGP MGI PMID:22118645 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lipa lysosomal acid lipase A IAGP MGI PMID:30639734 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lmna lamin A IAGP MGI PMID:21818413 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Mcat malonyl CoA:ACP acyltransferase (mitochondrial) IAGP MGI PMID:23077570 NCBI chr15:83,430,998...83,439,956
Ensembl chr15:83,430,998...83,447,988 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 IAGP MGI PMID:26344103 NCBI chr17:8,502,590...8,516,499
Ensembl chr17:8,501,736...8,516,493 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 IAGP MGI PMID:24910426 NCBI chr 1:165,288,829...165,308,787
Ensembl chr 1:165,288,206...165,308,783 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IAGP MGI PMID:19037247 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367 		JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 IAGP MGI PMID:21209089 NCBI chr15:4,055,910...4,184,826
Ensembl chr15:4,055,865...4,184,826 		JBrowse link
G Pank1 pantothenate kinase 1 IAGP MGI PMID:22815849 NCBI chr19:34,784,335...34,862,420
Ensembl chr19:34,784,340...34,856,855 		JBrowse link
G Pank2 pantothenate kinase 2 IAGP MGI PMID:22815849 NCBI chr 2:131,103,928...131,141,108
Ensembl chr 2:131,104,415...131,141,108 		JBrowse link
G Pax6 paired box 6 IAGP MGI PMID:15110714 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic IAGP MGI PMID:16300682 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcx pyruvate carboxylase IAGP MGI PMID:36441025 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 IAGP MGI PMID:33773101 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 IAGP MGI PMID:33773101 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 IAGP MGI PMID:33773101 NCBI chr  X:92,798,923...92,875,756
Ensembl chr  X:92,808,213...92,875,807 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 IAGP MGI PMID:16606348 PMID:33773101 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha IAGP MGI PMID:23169785 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Phkb phosphorylase kinase beta IAGP MGI PMID:36077341 NCBI chr 8:86,567,489...86,790,880
Ensembl chr 8:86,567,588...86,788,005 		JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 IAGP MGI PMID:36719796 NCBI chr 2:24,865,235...24,944,084
Ensembl chr 2:24,866,045...24,944,069 		JBrowse link
G Pygl liver glycogen phosphorylase IAGP MGI PMID:31701076 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 IAGP MGI PMID:21357625 NCBI chr 1:153,616,099...153,621,214
Ensembl chr 1:153,616,095...153,621,214 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 IAGP MGI PMID:21179166 NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 IAGP MGI PMID:12177411 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 IAGP MGI PMID:26596471 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial IAGP MGI PMID:7493016 PMID:11677043 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:21179166 PMID:26344103 PMID:30639734 PMID:36441025 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 IAGP MGI PMID:19564420 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase IAGP MGI PMID:19651815 NCBI chr 8:35,296,333...35,432,844
Ensembl chr 8:35,293,614...35,432,844 		JBrowse link
G Txnip thioredoxin interacting protein IAGP MGI PMID:16254043 PMID:18322014 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 IAGP MGI PMID:19273596 NCBI chr16:42,728,008...43,462,442
Ensembl chr16:42,696,244...43,462,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16233
    homeostasis/metabolism phenotype 7358
      abnormal homeostasis 6527
        ketosis 53
          increased circulating ketone body level 50
Path 2
Term Annotations click to browse term
  mammalian phenotype 16233
    homeostasis/metabolism phenotype 7358
      abnormal homeostasis 6527
        abnormal lipid homeostasis 1878
          abnormal circulating ketone body level 69
            increased circulating ketone body level 50
paths to the root