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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:preference for addictive substance
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Accession:MP:0002553 term browser browse the term
Definition:strong predilection for an addictive substance


show annotations for term's descendants           Sort by:
addiction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor severity IMP WT compared to heterozygous rats RGD PMID:23583595 PMID:23583595 RGD:38501054, RGD:38501054 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP RGD PMID:23583595 RGD:38501054
G Grm2 glutamate metabotropic receptor 2 IMP knockout compared to wild type RGD PMID:28700935 RGD:38501064 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 RGD:38501064
alcohol preference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IAGP DNA:polymorphism RGD PMID:11825850 RGD:2306323 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member IAGP DNA:polymorphism RGD PMID:15900217 RGD:2306341 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Arrb2 arrestin, beta 2 IAGP RGD PMID:18367649 RGD:401938607 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IAGP DNA:polymorphism, missense mutation:promoter, cds RGD PMID:24611993 RGD:8662401 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 IAGP DNA:polymorphism:CDS:amino acid R100Q, Q allele higher in the alcohol preferring ANA line than the AA non-preferring line (P<0.0001) RGD PMID:14615016 RGD:1626511 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Npy neuropeptide Y IAGP as compared to NP/Iusm; RGD PMID:27461754 RGD:11530013 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npyem6Sage neuropeptide Y; zinc finger nuclease induced mutant 6, Sigma Advanced Genetic Engineering Labs IAGP as compared to NP/Iusm; RGD PMID:27461754 RGD:11530013
cocaine preference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor severity IMP RGD PMID:23583595 RGD:38501054 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP RGD PMID:23583595 RGD:38501054
high preference for an addictive substance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor ameliorates IMP WT compared to heterozygous rats RGD PMID:23583595 RGD:38501054 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage ameliorates IMP WT compared to heterozygous rats RGD PMID:23583595 RGD:38501054
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit IMP compared to wild type RGD PMID:31288250 RGD:150530288 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna5em20(D398N)Pas cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas IMP compared to wild type RGD PMID:31288250 RGD:150530288
G Grm2 glutamate metabotropic receptor 2 IMP knock-out compared to wild-type rats RGD PMID:30283001 RGD:38501063 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:30283001 RGD:38501063
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    behavior/neurological phenotype 609
      abnormal behavior 608
        abnormal behavioral response to xenobiotic 140
          preference for addictive substance 81
            addiction 5
            alcohol preference 71
            cocaine preference 3
            high preference for an addictive substance 9
            low preference for an addictive substance 0
paths to the root