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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal T cell physiology
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Accession:MP:0002444 term browser browse the term
Definition:any functional anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation
Synonyms:exact_synonym: abnormal T cell function;   abnormal T lymphocyte function
 narrow_synonym: T-cell dysfunction;   t lymphocyte dysfunction



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decreased T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd247 Cd247 molecule IMP compared to wild-type RGD PMID:24343121 RGD:13442481 NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
JBrowse link
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:24343121 RGD:13442481
increased T cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
increased T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Themis thymocyte selection associated IAGP DNA:frameshift mutation: RGD PMID:22275874 RGD:38599149 NCBI chr 1:16,433,906...16,623,889
Ensembl chr 1:16,432,631...16,664,329
JBrowse link
G Themism1Adej thymocyte selection associated; mutant1, Adej IAGP compared to BN RGD PMID:22275874 RGD:38599149

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  mammalian phenotype 5402
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune cell physiology 56
          abnormal leukocyte physiology 56
            abnormal lymphocyte physiology 49
              abnormal T cell physiology 14
                abnormal CD4-positive, alpha-beta T cell physiology + 0
                abnormal CD8-positive, alpha-beta T cell physiology + 0
                abnormal NK T cell physiology 0
                abnormal T cell activation + 10
                abnormal T cell apoptosis + 5
                abnormal memory T cell physiology + 0
                abnormal regulatory T cell physiology + 0
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