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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal CD8-positive, alpha-beta cytotoxic T cell morphology
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Accession:MP:0002436 term browser browse the term
Definition:any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner
Comment:Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
Synonyms:exact_synonym: abnormal CD8-positive, alpha-beta cytotoxic T lymphocyte morphology
 broad_synonym: abnormal CTL morphology;   abnormal cytotoxic T cell morphology;   abnormal cytotoxic T lymphocyte morphology;   cytotoxic T cell abnormalities
 xref: CL:0000794

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  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system cell morphology 147
          abnormal leukocyte morphology 147
            abnormal mononuclear cell morphology 120
              abnormal lymphocyte morphology 98
                abnormal T cell morphology 68
                  abnormal effector T cell morphology 23
                    abnormal CD8-positive, alpha beta T cell morphology 11
                      abnormal CD8-positive, alpha-beta cytotoxic T cell morphology 0
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