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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal CD4-positive, alpha beta T cell morphology
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Accession:MP:0002432 term browser browse the term
Definition:any structural anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Comment:Generally, when immunologists write CD8 positive T cell, what they mean is CD8-positive, alpha-beta T cell (CL:0000625). Similarly, when immunologists write CD4 positive T cell, what they mean is CD4-positive, alpha-beta T cell (CL:0000624). T cells bearing the alpha-beta T cell receptor are the most common in the body, and are the most commonly studied, so much so, that in many published papers, the authors do not even bother to specify (or assume) they are studying alpha-beta T cells and thus omit saying so.
Synonyms:exact_synonym: CD4+ T-cell abnormalities;   abnormal CD4+ T cell morphology;   abnormal CD4-positive T cell morphology
 broad_synonym: abnormal single positive T cell morphology


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  mammalian phenotype 0
    immune system phenotype 0
      abnormal immune system morphology 0
        abnormal immune system cell morphology 0
          abnormal leukocyte morphology 0
            abnormal mononuclear cell morphology 0
              abnormal lymphocyte morphology 0
                abnormal T cell morphology 0
                  abnormal effector T cell morphology 0
                    abnormal CD4-positive, alpha beta T cell morphology 0
                      abnormal CD4-positive T cell differentiation + 0
                      abnormal CD4-positive helper T cell morphology + 0
                      abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology + 0
                      abnormal CD4-positive, alpha-beta T cell number + 0
                      abnormal CD4-positive, alpha-beta intraepithelial T cell morphology 0
                      abnormal CD4-positive, alpha-beta memory T cell morphology + 0
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