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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal type II pneumocyte morphology
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Accession:MP:0002275 term browser browse the term
Definition:any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored
Synonyms:exact_synonym: abnormal AT2 morphology;   abnormal ATII morphology;   abnormal Cuboidal type II cell morphology;   abnormal Great alveolar cells morphology;   abnormal Lung type 2 cells morphology;   abnormal Lung type II cells morphology;   abnormal TII morphology;   abnormal granular pneumocytes morphology;   abnormal type 2 alveolar epithelial cells morphology;   abnormal type 2 alveolocytes morphology;   abnormal type 2 pneumocyte morphology;   abnormal type II alveolar epithelial cells morphology;   abnormal type II alveolocytes morphology;   abnormal type II cells morphology;   abnormal type II pneumocytes morphology;   abnormal type II pneumonocytes morphology
 xref: CL:0002063;   FMA:62501


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enlarged alveolar lamellar bodies term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:24465451 RGD:13462051 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24465451 RGD:13462051
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:28438206 RGD:13524861 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Rab38ru Rab38, member of RAS oncogene family, ruby allele IMP RGD PMID:28438206 RGD:13524861
increased alveolar lamellar body number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:24244710 RGD:12880447 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24244710 RGD:12880447
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    respiratory system phenotype 47
      abnormal respiratory system morphology 33
        abnormal lung morphology 26
          abnormal lung epithelium morphology 6
            abnormal pulmonary alveolus epithelium morphology 6
              abnormal pulmonary alveolus epithelial cell morphology 6
                abnormal type II pneumocyte morphology 6
                  abnormal alveolar lamellar body morphology + 6
                  decreased type II pneumocyte number + 0
                  increased type II pneumocyte number + 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    respiratory system phenotype 47
      abnormal respiratory system morphology 33
        abnormal lung morphology 26
          abnormal pulmonary alveolar system morphology 7
            abnormal pulmonary acinus morphology 7
              abnormal pulmonary alveolus morphology 7
                abnormal pulmonary alveolus epithelium morphology 6
                  abnormal pulmonary alveolus epithelial cell morphology 6
                    abnormal type II pneumocyte morphology 6
                      abnormal alveolar lamellar body morphology + 6
                      decreased type II pneumocyte number + 0
                      increased type II pneumocyte number + 0
paths to the root