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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal fertility/fecundity
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Accession:MP:0002161 term browser browse the term
Definition:anomaly in the reproductive capability of an organism or population to produce live offspring
Synonyms:exact_synonym: abnormal fecundity;   reproductive system: fertility/fecundity anomalies
 alt_id: MP:0001920
 xref: MGI:2173621


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decreased litter size term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin IMP RGD PMID:28859281 RGD:13464336 NCBI chr 7:122,517,910...122,524,110
Ensembl chr 7:122,517,934...122,524,087 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 IMP compared to wild type RGD PMID:29444903 RGD:150429710 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp2c11em1Nju cytochrome P450, subfamily 2, polypeptide 11; CRISPR/Cas9 induced mutant 1, Nju IMP compared to wild type RGD PMID:29444903 RGD:150429710
G Defb23em2MlitDefb26em2Mlit defensin beta 23, defensin beta 26; CRISPR/Cas9 induced mutant2, Mlit IMP RGD PMID:29141997 RGD:13782190
G Fh fumarate hydratase IMP RGD PMID:27556703 RGD:13792708 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627 		JBrowse link
G Fhem1 fumarate hydratase; TALEN induced mutant 1 IMP RGD PMID:27556703 RGD:13792708
G Mmp12 matrix metallopeptidase 12 IMP RGD PMID:27807143 RGD:12910498 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478 		JBrowse link
G Mmp12em2Soar matrix metallopeptidase 12; TALEN induced mutant 2,Soar IMP RGD PMID:27807143 RGD:12910498
G Nkx3-1 NK3 homeobox 1 IMP compared to wild type RGD PMID:33368416 RGD:150573817 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nkx3-1em1Pjhak NK3 homeobox 1; TALEN induced mutant 1, Pjhak IMP compared to wild type RGD PMID:33368416 RGD:150573817
delayed fertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 IMP compared to wild type RGD PMID:29444903 RGD:150429710 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853 		JBrowse link
G Cyp2c11em1Nju cytochrome P450, subfamily 2, polypeptide 11; CRISPR/Cas9 induced mutant 1, Nju IMP compared to wild type RGD PMID:29444903 RGD:150429710
female infertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 IMP RGD PMID:29580824 RGD:38548925 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Esr2em1Soar estrogen receptor 2; ZFN induced mutant 1, Soar IMP RGD PMID:29580824 RGD:38548925
increased litter size term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inha inhibin subunit alpha IDA rat transgene introduced into female mice RGD PMID:15359127 RGD:2290396 NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009 		JBrowse link
infertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnd1 DND microRNA-mediated repression inhibitor 1 IAGP compared to WKY RGD PMID:22655094 RGD:40924659 NCBI chr18:28,652,712...28,655,336
Ensembl chr18:28,652,712...28,655,336 		JBrowse link
G Dnd1ter DND microRNA-mediated repression inhibitor 1, ter mutant IAGP compared to WKY RGD PMID:22655094 RGD:40924659
G Ngly1 N-glycanase 1 IMP RGD PMID:32259258 RGD:39457703 NCBI chr15:11,584,475...11,640,977
Ensembl chr15:11,584,475...11,635,328 		JBrowse link
G Ngly1em1Ta N-glycanase 1; CRISPR/Cas9 induced mutant 1, Ta IMP RGD PMID:32259258 RGD:39457703
G Tshr thyroid stimulating hormone receptor IMP RGD PMID:29507327 RGD:150521601 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010 		JBrowse link
G Tshrem1Mlit thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit IMP RGD PMID:29507327 RGD:150521601
male infertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sbf1 SET binding factor 1 IAGP DNA:substitution:intron 37:G>A (rat) RGD PMID:27335132 RGD:38549340 NCBI chr 7:122,237,968...122,264,591
Ensembl chr 7:122,237,968...122,264,531 		JBrowse link
G Sbf1m1Ipcv SET binding factor 1; mutation 1, Institute of Physiology, Czechoslovac Academy of Sciences IAGP RGD PMID:27335132 RGD:38549340
reduced fertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP in KO rat RGD PMID:30893315 RGD:126908018 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018
reduced male fertility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdk branched chain ketoacid dehydrogenase kinase IAGP DNA:missense mutation:cds:G369E (rat) RGD PMID:27472223 RGD:39131293 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:191,946,471...191,953,453 		JBrowse link
G Nkx3-1 NK3 homeobox 1 IMP compared to wild type RGD PMID:33368416 RGD:150573817 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nkx3-1em1Pjhak NK3 homeobox 1; TALEN induced mutant 1, Pjhak IMP compared to wild type RGD PMID:33368416 RGD:150573817
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    reproductive system phenotype 129
      abnormal reproductive system physiology 64
        abnormal fertility/fecundity 47
          abnormal litter size + 20
          delayed fertility + 4
          delayed reproductive senescence 0
          early reproductive senescence + 0
          enhanced fertility + 1
          infertility + 18
          reduced fertility + 27
paths to the root