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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased circulating insulin level
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Accession:MP:0002079 term browser browse the term
Definition:greater than normal levels of insulin in blood
Synonyms:exact_synonym: hyperinsulinaemia;   hyperinsulinemia;   hyperinsulinism
 related_synonym: Type II diabetes mellitus
 xref: HP:0005978



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increased circulating insulin level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin IMP RGD PMID:25934999 RGD:11085488 NCBI chr 1:205,731,828...205,743,430 JBrowse link
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo IMP RGD PMID:25934999 RGD:11085488
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 IMP compared to wild type RGD PMID:29656108 RGD:150520032 NCBI chr 5:116,295,691...116,323,219 JBrowse link
G Cyp2j4em1Sage cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage IMP compared to wild type RGD PMID:29656108 RGD:150520032
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:184,490,840...184,492,456 JBrowse link
G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989
G Insr insulin receptor induced IMP RGD PMID:19017805 RGD:2314405 NCBI chr12:5,991,135...6,129,275 JBrowse link
G Lepr leptin receptor IMP
IAGP
DNA:mutations:cds: : (rat) RGD PMID:27465994 PMID:28746409 RGD:12911217, RGD:401965413 NCBI chr 5:121,409,735...121,593,201 JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:27465994 RGD:12911217
G Mc4r melanocortin 4 receptor IMP RGD PMID:24400148 RGD:13825242 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:24400148 RGD:13825242

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5421
    homeostasis/metabolism phenotype 1426
      abnormal homeostasis 1327
        abnormal glucose homeostasis 355
          abnormal circulating insulin level 108
            increased circulating insulin level 87
Path 2
Term Annotations click to browse term
  mammalian phenotype 5421
    homeostasis/metabolism phenotype 1426
      abnormal homeostasis 1327
        abnormal blood homeostasis 764
          abnormal circulating hormone level 293
            abnormal circulating insulin level 108
              increased circulating insulin level 87
paths to the root