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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased tumor incidence
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Accession:MP:0002020 term browser browse the term
Definition:greater than the expected number of neoplasms in a specific population in a given time period, usually of a specific type
Synonyms:exact_synonym: increased neoplasm incidence;   increased tumour incidence;   spontaneous tumor
 broad_synonym: Neoplasm
 alt_id: MP:0002017
 xref: HP:0002664


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increased tumor incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IMP RGD PMID:16964288 RGD:1599505 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194 		JBrowse link
G Brca2m1Uwm BRCA2, DNA repair associated; mutation 1, University of Wisconsin-Madison IMP RGD PMID:16964288 RGD:1599505
G Msh6 mutS homolog 6 IMP RGD PMID:18417481 RGD:2292505 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Msh6m1Hubr mutS homolog 6; ENU induced mutant 1, Hubr IMP RGD PMID:18417481 RGD:2292505
G Tp53 tumor protein p53 IMP RGD PMID:22917926 RGD:11075077 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53em1Sage tumor protein p53; ZFN induced mutant 1, Sage IMP RGD PMID:22917926 RGD:11075077
increased colon adenoma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway IMP compared to treated females, mock treated males RGD PMID:17360473 RGD:1601201 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G ApcPirc APC, WNT signaling pathway regulator; polyposis in the rat colon IMP compared to treated females, mock treated males RGD PMID:17360473 RGD:1601201
increased incidence of induced tumors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag2 recombination activating 2 induced IMP XCO:0000709 RGD PMID:30206106 RGD:38508903 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:108,357,399...108,365,253 		JBrowse link
increased intestinal adenocarcinoma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway sexual_dimorphism IMP compared to treated females RGD PMID:17360473 RGD:1601201 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G ApcPirc APC, WNT signaling pathway regulator; polyposis in the rat colon sexual_dimorphism IMP compared to treated females RGD PMID:17360473 RGD:1601201
increased mesothelioma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A IAGP DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IAGP DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855 		JBrowse link
increased osteosarcoma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 IAGP DNA:deletion RGD PMID:19825367 RGD:5147850 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
increased pheochromocytoma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IAGP RGD PMID:12036912 RGD:619590 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn1bwe cyclin-dependent kinase inhibitor 1B; white eye mutation IAGP RGD PMID:12036912 RGD:619590
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    neoplasm 244
      abnormal tumor susceptibility 236
        abnormal tumor incidence 225
          increased tumor incidence 166
            increased classified tumor incidence + 105
            increased incidence of induced tumors + 19
            increased organ/body region tumor incidence + 139
paths to the root