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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal humoral immune response
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Accession:MP:0001800 term browser browse the term
Definition:any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination
Synonyms:exact_synonym: abnormal humoural immune response;   antibody-mediated immune response abnormalities;   humoral immune response dysfunction;   humoural immune response dysfunction


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  mammalian phenotype 0
    immune system phenotype 0
      abnormal immune system physiology 0
        abnormal humoral immune response 0
          abnormal complement pathway + 0
          abnormal immunoglobulin level + 0
          enhanced humoral immune response 0
          impaired humoral immune response 0
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