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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased metastatic potential
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Accession:MP:0001272 term browser browse the term
Definition:greater likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it
Synonyms:exact_synonym: elevated metastatic potential;   increase in metastasis potential;   increase in potential to develop metastases


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increased metastatic potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing IAGP MGI PMID:19319191 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:18687666 PMID:19237610 PMID:22331912 PMID:25815421 NCBI chr15:102,353,437...102,363,075
Ensembl chr15:102,353,802...102,363,068 		JBrowse link
G Apc APC, WNT signaling pathway regulator IAGP MGI PMID:21251616 PMID:22158121 PMID:22452792 PMID:23955540 PMID:26411367 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Arid1a AT rich interactive domain 1A (SWI-like) IAGP MGI PMID:25625625 NCBI chr 4:133,406,319...133,484,682
Ensembl chr 4:133,406,319...133,484,080 		JBrowse link
G Atf2 activating transcription factor 2 IAGP MGI PMID:10694580 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 IAGP MGI PMID:30237863 NCBI chr 5:124,767,117...124,801,519
Ensembl chr 5:124,766,641...124,801,519 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 IAGP MGI PMID:16397237 NCBI chr 5:144,127,104...144,131,259
Ensembl chr 5:144,127,104...144,131,259 		JBrowse link
G Braf Braf transforming gene IAGP MGI PMID:19282848 PMID:21383153 PMID:22836754 PMID:23845441 PMID:24711431 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Brca1 breast cancer 1, early onset IAGP MGI PMID:22617326 PMID:22777348 PMID:24120138 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha IAGP MGI PMID:23047698 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 IAGP MGI PMID:25497869 NCBI chr16:44,913,770...44,948,287
Ensembl chr16:44,913,765...44,948,440 		JBrowse link
G Ccn6 cellular communication network factor 6 IAGP MGI PMID:27819674 NCBI chr10:39,026,966...39,049,484
Ensembl chr10:39,026,966...39,039,790 		JBrowse link
G Cd226 CD226 antigen IAGP MGI PMID:19029380 NCBI chr18:89,195,078...89,290,356
Ensembl chr18:89,195,091...89,290,353 		JBrowse link
G Cd44 CD44 antigen IAGP MGI PMID:16061657 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cdh1 cadherin 1 IAGP MGI PMID:17097565 PMID:21282721 PMID:24784840 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh13 cadherin 13 IAGP MGI PMID:18316604 NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660 		JBrowse link
G Cdk4 cyclin dependent kinase 4 IAGP MGI PMID:16877364 PMID:28096290 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A (P21) IAGP MGI PMID:12810620 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IAGP MGI PMID:11544530 PMID:14681207 PMID:15314658 PMID:15899789 PMID:16585505 More... NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C IAGP MGI PMID:22777348 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Commd10 COMM domain containing 10 IAGP MGI PMID:30237863 NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351 		JBrowse link
G Cst3 cystatin C IAGP MGI PMID:10748866 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 IAGP MGI PMID:18687666 PMID:19237610 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dcc deleted in colorectal carcinoma IAGP MGI PMID:22158121 PMID:22358843 NCBI chr18:71,386,703...72,484,299
Ensembl chr18:71,386,705...72,484,140 		JBrowse link
G Dicer1 dicer 1, ribonuclease type III IAGP MGI PMID:22331912 PMID:25815421 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211 		JBrowse link
G E2f1 E2F transcription factor 1 IAGP MGI PMID:8653789 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Ednrb endothelin receptor type B IAGP MGI PMID:20048069 NCBI chr14:104,052,051...104,083,248
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Epha2 Eph receptor A2 IAGP MGI PMID:16849550 NCBI chr 4:141,028,532...141,056,695
Ensembl chr 4:141,028,551...141,056,695 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IAGP MGI PMID:18381417 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IAGP MGI PMID:20418913 NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349 		JBrowse link
G Espl1 extra spindle pole bodies 1, separase IAGP MGI PMID:21799785 NCBI chr15:102,204,688...102,232,792
Ensembl chr15:102,204,701...102,232,792 		JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) IAGP MGI PMID:16935260 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 IAGP MGI PMID:20068154 NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha IAGP MGI PMID:16141330 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:20407033 PMID:25180607 PMID:25625625 PMID:26113083 PMID:28790031 More... NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hic1 hypermethylated in cancer 1 IAGP MGI PMID:12539045 NCBI chr11:75,052,203...75,059,970
Ensembl chr11:75,055,391...75,060,345 		JBrowse link
G Hltf helicase-like transcription factor IAGP MGI PMID:22452792 NCBI chr 3:20,111,959...20,172,655
Ensembl chr 3:20,111,975...20,172,654 		JBrowse link
G Hmga2 high mobility group AT-hook 2 IAGP MGI PMID:28790031 NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374 		JBrowse link
G Hmgn1 high mobility group nucleosomal binding domain 1 IAGP MGI PMID:16061652 NCBI chr16:95,922,788...95,928,925
Ensembl chr16:95,921,818...95,928,929 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 IAGP MGI PMID:14695192 NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:19734231 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ifngr1 interferon gamma receptor 1 IAGP MGI PMID:19734231 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Il5 interleukin 5 IAGP MGI PMID:22174445 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il5ra interleukin 5 receptor, alpha IAGP MGI PMID:22174445 NCBI chr 6:106,687,336...106,725,998
Ensembl chr 6:106,687,318...106,725,998 		JBrowse link
G Immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) IAGP MGI PMID:18097012 NCBI chr12:41,074,060...42,002,371
Ensembl chr12:41,074,089...42,002,371 		JBrowse link
G Itgal integrin alpha L IAGP MGI PMID:8955185 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:14681207 PMID:15619626 PMID:16288016 PMID:16585505 PMID:17114585 More... NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Krt14 keratin 14 IAGP MGI PMID:22975380 PMID:28096290 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374 		JBrowse link
G Lep leptin IAGP MGI PMID:16998795 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor IAGP MGI PMID:16998795 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 IAGP MGI PMID:26456157 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536 		JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP MGI PMID:17893233 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Mmp11 matrix metallopeptidase 11 IAGP MGI PMID:14522908 NCBI chr10:75,759,056...75,768,336
Ensembl chr10:75,759,056...75,772,330 		JBrowse link
G Msmb beta-microseminoprotein IAGP MGI PMID:15674347 NCBI chr14:31,863,980...31,880,284
Ensembl chr14:31,863,980...31,880,327 		JBrowse link
G Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein IAGP MGI PMID:17906694 NCBI chr15:55,420,800...55,489,819
Ensembl chr15:55,420,804...55,489,819 		JBrowse link
G Nf1 neurofibromin 1 IAGP MGI PMID:23412344 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nf2 neurofibromin 2 IAGP MGI PMID:18328429 NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536 		JBrowse link
G Nkx3-1 NK3 homeobox 1 IAGP MGI PMID:22836754 NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111 		JBrowse link
G Nmi N-myc (and STAT) interactor IAGP MGI PMID:29326438 NCBI chr 2:51,838,510...51,863,505
Ensembl chr 2:51,838,499...51,863,506 		JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP MGI PMID:25775533 NCBI chr 3:90,357,898...90,373,235
Ensembl chr 3:90,357,898...90,373,173 		JBrowse link
G Nras neuroblastoma ras oncogene IAGP MGI PMID:25252692 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Pard3 par-3 family cell polarity regulator IAGP MGI PMID:22975380 PMID:28096290 NCBI chr 8:127,790,131...128,338,767
Ensembl chr 8:127,790,643...128,338,767 		JBrowse link
G Pgr progesterone receptor IAGP MGI PMID:20418913 PMID:23820898 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pkm pyruvate kinase, muscle IAGP MGI PMID:24120138 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha IAGP MGI PMID:24512487 NCBI chr11:109,539,849...109,560,489
Ensembl chr11:109,540,231...109,560,482 		JBrowse link
G Ptch1 patched 1 IAGP MGI PMID:24141783 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:11178110 PMID:15199412 PMID:15619626 PMID:16488991 PMID:16489020 More... NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptf1a pancreas specific transcription factor, 1a IAGP MGI PMID:17114585 PMID:18713982 NCBI chr 2:19,450,474...19,452,312
Ensembl chr 2:19,450,474...19,452,312 		JBrowse link
G Rasal2 RAS protein activator like 2 IAGP MGI PMID:24029233 NCBI chr 1:156,962,759...157,240,170
Ensembl chr 1:156,962,752...157,240,165 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IAGP MGI PMID:8134105 PMID:12839925 PMID:17893233 PMID:18559481 PMID:23047698 More... NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rnf19b ring finger protein 19B IAGP MGI PMID:19915045 NCBI chr 4:128,951,871...128,978,319
Ensembl chr 4:128,952,064...128,979,679 		JBrowse link
G Rpl27a ribosomal protein L27A IAGP MGI PMID:21674502 NCBI chr 7:109,118,354...109,121,967
Ensembl chr 7:109,118,354...109,121,574 		JBrowse link
G Runx1 runt related transcription factor 1 IAGP MGI PMID:16081688 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) IAGP MGI PMID:26123588 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Setd4 SET domain containing 4 IAGP MGI PMID:31794893 NCBI chr16:93,380,345...93,401,693
Ensembl chr16:93,380,345...93,400,951 		JBrowse link
G Smad3 SMAD family member 3 IAGP MGI PMID:9753318 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 IAGP MGI PMID:22341455 PMID:23999427 PMID:24784840 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:15199412 PMID:22266220 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IAGP MGI PMID:20215508 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stk11 serine/threonine kinase 11 IAGP MGI PMID:17676035 PMID:20142330 PMID:25252692 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Tbx21 T-box 21 IAGP MGI PMID:14744755 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tert telomerase reverse transcriptase IAGP MGI PMID:22341455 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II IAGP MGI PMID:17114585 PMID:21911454 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Th tyrosine hydroxylase IAGP MGI PMID:22764207 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tle5 TLE family member 5, transcriptional modulator IAGP MGI PMID:21251616 NCBI chr10:81,395,278...81,402,205
Ensembl chr10:81,395,322...81,402,196 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b IAGP MGI PMID:18079967 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Tom1l2 target of myb1-like 2 (chicken) IAGP MGI PMID:18343975 NCBI chr11:60,114,622...60,243,766
Ensembl chr11:60,117,540...60,243,731 		JBrowse link
G Tpx2 TPX2, microtubule-associated IAGP MGI PMID:22266221 NCBI chr 2:152,689,859...152,737,241
Ensembl chr 2:152,689,884...152,737,241 		JBrowse link
G Trim16 tripartite motif-containing 16 IAGP MGI PMID:31342168 NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634 		JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:10760284 PMID:12839925 PMID:15607980 PMID:15607981 PMID:15837625 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp63 transformation related protein 63 IAGP MGI PMID:15837625 NCBI chr16:25,502,513...25,710,838
Ensembl chr16:25,502,513...25,710,852 		JBrowse link
G Trp73 transformation related protein 73 IAGP MGI PMID:15837625 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
G Tsc1 TSC complex subunit 1 IAGP MGI PMID:26777415 NCBI chr 2:28,531,005...28,581,183
Ensembl chr 2:28,531,240...28,581,179 		JBrowse link
G Tsc2 TSC complex subunit 2 IAGP MGI PMID:23820898 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Usp11 ubiquitin specific peptidase 11 IAGP MGI PMID:30733438 NCBI chr  X:20,570,148...20,586,778
Ensembl chr  X:20,570,145...20,586,778 		JBrowse link
G Xpa xeroderma pigmentosum, complementation group A IAGP MGI PMID:16117793 NCBI chr 4:46,175,222...46,196,345
Ensembl chr 4:46,155,347...46,196,311 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C IAGP MGI PMID:16141330 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 16242
    neoplasm 1315
      abnormal tumor pathology 387
        abnormal metastatic potential 167
          increased metastatic potential 102
paths to the root