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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal midbrain morphology
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Accession:MP:0000897 term browser browse the term
Definition:any structural anomaly associated with the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes
Synonyms:exact_synonym: abnormal mesencephalon morphology;   mesencephalon dysplasia;   midbrain dysplasia


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abnormal substantia nigra pars compacta morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 IMP compared to wild-type and untreated RGD PMID:29530712 RGD:40924655 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a1m1Mcwi nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin IMP compared to wild-type and untreated RGD PMID:29530712 RGD:40924655
decreased substantia nigra cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pink1 PTEN induced kinase 1 IMP compared to LEH RGD PMID:25421206 RGD:11560775 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pink1em1Sage PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP compared to LEH RGD PMID:25421206 RGD:11560775
decreased substantia nigra size term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pink1 PTEN induced kinase 1 IMP compared to LEH RGD PMID:25421206 RGD:11560775 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pink1em1Sage PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP compared to LEH RGD PMID:25421206 RGD:11560775
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5419
    nervous system phenotype 378
      abnormal nervous system morphology 216
        abnormal brain morphology 140
          abnormal brainstem morphology 13
            abnormal midbrain morphology 7
              abnormal cerebral aqueduct morphology + 0
              abnormal midbrain roof plate morphology + 0
              abnormal midbrain size + 0
              abnormal oculomotor nucleus morphology 0
              abnormal pretectal region morphology + 0
              abnormal substantia nigra morphology + 7
              abnormal tegmentum morphology + 0
              abnormal trigeminal V mesencephalic nucleus morphology + 0
              absent midbrain 0
              midbrain atrophy 0
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