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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal thymus morphology
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Accession:MP:0000703 term browser browse the term
Definition:any structural anomaly of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies; the thymus also stimulates the production of certain pituitary gland hormones that promote growth and sexual maturation
Synonyms:exact_synonym: abnormal thymic morphology;   abnormal thymus structure;   thymus abnormalities;   thymus dysplasia
 alt_id: MP:0002366


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abnormal thymus morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator IMP RGD PMID:29959280 RGD:38599145 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060 		JBrowse link
G Aireem1Ang autoimmune regulator; ZFN induced mutant1, Ang IMP RGD PMID:29959280 RGD:38599145
athymia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 IAGP RGD PMID:8790387 RGD:1300512 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
decreased thymocyte number term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:29688994 RGD:13628403 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang IMP RGD PMID:29688994 RGD:13628403
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
G Rag1 recombination activating 1 IMP RGD PMID:29688994 RGD:13628403 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:29688994 RGD:13628403
decreased thymus weight term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednrb endothelin receptor type B IAGP RGD PMID:22975636 RGD:7207471 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Ednrbsl endothelin receptor type B, spotting lethal IAGP RGD PMID:22975636 RGD:7207471
G Pmch pro-melanin-concentrating hormone induces IMP RGD PMID:19934402 RGD:150429945 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Pmchm1Hubr pro-melanin-concentrating hormone; ENU induced mutant1, Hubr induces IMP RGD PMID:19934402 RGD:150429945
G Rag1 recombination activating 1 IMP RGD PMID:23364523 RGD:7207429 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:23364523 RGD:7207429
G Rag1em2Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:23364523 RGD:7207429
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
increased thymus weight term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP in KO rat RGD PMID:30893315 RGD:126908018 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018
G Tmem67 transmembrane protein 67 IAGP RGD PMID:15052665 RGD:15014788 NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
G Tmem67wpk transmembrane protein 67; wpk mutant IAGP RGD PMID:15052665 RGD:15014788
small thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 IAGP RGD PMID:11832364 RGD:727991 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
G Rag1 recombination activating 1 IMP RGD PMID:23150522 PMID:23136839 RGD:7204134, RGD:7204131 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon IMP RGD PMID:23150522 RGD:7204134
G Rag1em1Ztm recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover IMP RGD PMID:23136839 RGD:7204131
thymus hypoplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma IMP RGD PMID:20111598 RGD:2316325 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5374
    hematopoietic system phenotype 243
      abnormal hematopoietic system morphology/development 223
        abnormal thymus morphology 61
          abnormal thymus capsule morphology 0
          abnormal thymus cell ratio 0
          abnormal thymus development + 0
          abnormal thymus epithelium morphology + 0
          abnormal thymus lobule morphology + 0
          abnormal thymus size + 54
          abnormal thymus topology 0
          abnormal thymus trabecula morphology 0
          athymia 2
          decreased thymocyte number + 9
          ectopic thymus 0
          increased thymocyte number + 0
          thymus cyst 0
          thymus fibrosis 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5374
    immune system phenotype 492
      abnormal immune system morphology 187
        abnormal immune system organ morphology 73
          abnormal thymus morphology 61
            abnormal thymus capsule morphology 0
            abnormal thymus cell ratio 0
            abnormal thymus development + 0
            abnormal thymus epithelium morphology + 0
            abnormal thymus lobule morphology + 0
            abnormal thymus size + 54
            abnormal thymus topology 0
            abnormal thymus trabecula morphology 0
            athymia 2
            decreased thymocyte number + 9
            ectopic thymus 0
            increased thymocyte number + 0
            thymus cyst 0
            thymus fibrosis 0
paths to the root