MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: spleen hyperplasia
Accession: MP:0000693
browse the term
Definition: increase in the number of normal cells in normal arrangement in the spleen, typically resulting in increased size
Synonyms: exact_synonym: hyperplastic spleen; increased spleen cellularity; splenic hyperplasia
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Ackr4
atypical chemokine receptor 4
IAGP
MGI
PMID:20562329
NCBI chr 9:103,974,881...104,003,842
Ensembl chr 9:103,961,356...104,004,132
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Adam10
a disintegrin and metallopeptidase domain 10
IAGP
MGI
PMID:22042698
NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511
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Asxl1
ASXL transcriptional regulator 1
IAGP
MGI
PMID:19861679
NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
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Bcl11b
B cell leukemia/lymphoma 11B
IAGP
MGI
PMID:17998389
NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861
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Bcl2l11
BCL2 like 11
IAGP
MGI
PMID:10576740 PMID:18275831
NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
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Bcl6
B cell leukemia/lymphoma 6
IAGP
MGI
PMID:9171827
NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602
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Bhlhe40
basic helix-loop-helix family, member e40
IAGP
MGI
PMID:11668339
NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886
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Bmf
BCL2 modifying factor
IAGP
MGI
PMID:18299399
NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
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Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
IAGP
MGI
PMID:18048346
NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
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Card11
caspase recruitment domain family, member 11
IAGP
MGI
PMID:12818157
NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337
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Cbl
Casitas B-lineage lymphoma
IAGP
MGI
PMID:12591907 PMID:16211006
NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346
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Ccne1
cyclin E1
IAGP
MGI
PMID:18559482
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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Cd19
CD19 antigen
IAGP
MGI
PMID:23619366 PMID:26668357
NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061
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Cdkn1a
cyclin dependent kinase inhibitor 1A
IAGP
MGI
PMID:10655105
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cdkn1b
cyclin dependent kinase inhibitor 1B
IAGP
MGI
PMID:8646781
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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Cdkn2b
cyclin dependent kinase inhibitor 2B
IAGP
MGI
PMID:10880462
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
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Cdkn2c
cyclin dependent kinase inhibitor 2C
IAGP
MGI
PMID:9744866
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
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Cftr
cystic fibrosis transmembrane conductance regulator
IAGP
MGI
PMID:1380723
NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
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Cish
cytokine inducible SH2-containing protein
IAGP
MGI
PMID:23727894
NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
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Commd10
COMM domain containing 10
IAGP
MGI
PMID:21844204
NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351
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Cpt1c
carnitine palmitoyltransferase 1c
IAGP
MGI
PMID:23412344
NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275
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Csf3r
colony stimulating factor 3 receptor
IAGP
MGI
PMID:22042698
NCBI chr 4:125,917,241...125,938,233
Ensembl chr 4:125,918,343...125,938,233
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
IAGP
MGI
PMID:18845758
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
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Cycs
cytochrome c, somatic
IAGP
MGI
PMID:15907471
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
IAGP
MGI
PMID:15314222
NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
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Dido1
death inducer-obliterator 1
IAGP
MGI
PMID:16127461
NCBI chr 2:180,299,757...180,351,886
Ensembl chr 2:180,299,757...180,351,792
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Dtx1
deltex 1, E3 ubiquitin ligase
IAGP
MGI
PMID:19592273
NCBI chr 5:120,818,268...120,850,879
Ensembl chr 5:120,818,267...120,849,992
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Esr2
estrogen receptor 2 (beta)
IAGP
MGI
PMID:12740446
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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Fas
Fas cell surface death receptor
IAGP
MGI
PMID:9109438 PMID:18275831
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fcgr2b
Fc receptor, IgG, low affinity IIb
IAGP
MGI
PMID:23123062
NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116
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Fli1
Friend leukemia integration 1
IAGP
MGI
PMID:18641300
NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157
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Foxo3
forkhead box O3
IAGP
MGI
PMID:15308101
NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
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Foxp3
forkhead box P3
IAGP
MGI
PMID:18845758 PMID:27410049
NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484
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Gadd45b
growth arrest and DNA-damage-inducible 45 beta
IAGP
MGI
PMID:16287712
NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
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Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
IAGP
MGI
PMID:16287712
NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
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Gba1
glucosylceramidase beta 1
IAGP
MGI
PMID:20962279
NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273
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Gpr83
G protein-coupled receptor 83
IAGP
MGI
PMID:18479351
NCBI chr 9:14,771,038...14,782,085
Ensembl chr 9:14,771,506...14,782,085
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Gt(ROSA)26Sor
gene trap ROSA 26, Philippe Soriano
IAGP
MGI
PMID:18327259 PMID:20616797 PMID:23619366 PMID:26668357
NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336
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Hip1
huntingtin interacting protein 1
IAGP
MGI
PMID:19647224
NCBI chr 5:135,435,350...135,574,167
Ensembl chr 5:135,435,385...135,573,974
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Hmox1
heme oxygenase 1
IAGP
MGI
PMID:9380735
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hprt1
hypoxanthine phosphoribosyltransferase 1
IAGP
MGI
PMID:17018605
NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536
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Ikzf1
IKAROS family zinc finger 1
IAGP
MGI
PMID:7585946
NCBI chr11:11,634,970...11,722,930
Ensembl chr11:11,634,980...11,722,926
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Il10
interleukin 10
IAGP
MGI
PMID:19620304
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il10rb
interleukin 10 receptor, beta
IAGP
MGI
PMID:9463407
NCBI chr16:91,203,166...91,222,718
Ensembl chr16:91,203,052...91,222,722
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Il2rg
interleukin 2 receptor, gamma chain
IAGP
MGI
PMID:7697543
NCBI chr X:100,307,991...100,311,861
Ensembl chr X:100,307,984...100,311,861
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Il4
interleukin 4
IAGP
MGI
PMID:9109438
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Il6st
interleukin 6 signal transducer
IAGP
MGI
PMID:10661409
NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620
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Ing2
inhibitor of growth family, member 2
IAGP
MGI
PMID:21124965
NCBI chr 8:48,120,213...48,128,627
Ensembl chr 8:48,120,213...48,128,591
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Inpp5d
inositol polyphosphate-5-phosphatase D
IAGP
MGI
PMID:9620849
NCBI chr 1:87,548,034...87,648,232
Ensembl chr 1:87,548,034...87,648,229
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Irf8
interferon regulatory factor 8
IAGP
MGI
PMID:8861914
NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433
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Itfg2
integrin alpha FG-GAP repeat containing 2
IAGP
MGI
PMID:23997217
NCBI chr 6:128,386,407...128,401,873
Ensembl chr 6:128,386,407...128,401,894
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Itgal
integrin alpha L
IAGP
MGI
PMID:15955836
NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
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Kit
KIT proto-oncogene receptor tyrosine kinase
IAGP
MGI
PMID:15067126 PMID:22652566
NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
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Kitl
kit ligand
IAGP
MGI
PMID:22281595
NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
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Klf13
Kruppel-like transcription factor 13
IAGP
MGI
PMID:17442931 PMID:18285334
NCBI chr 7:63,536,099...63,588,663
Ensembl chr 7:63,536,099...63,588,663
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Lat
linker for activation of T cells
IAGP
MGI
PMID:12065839 PMID:15153499 PMID:17081783 PMID:19682930
NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742
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Lat2
linker for activation of T cells family, member 2
IAGP
MGI
PMID:17081783
NCBI chr 5:134,628,957...134,648,637
Ensembl chr 5:134,628,876...134,643,879
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Lcn2
lipocalin 2
IAGP
MGI
PMID:21507940
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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Lepr
leptin receptor
IAGP
MGI
PMID:22281595
NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
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Lgals9
lectin, galactose binding, soluble 9
IAGP
MGI
PMID:23118208
NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772
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Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
IAGP
MGI
PMID:17577922
NCBI chr17:49,238,630...49,404,619
Ensembl chr17:49,239,407...49,404,616
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Ltb
lymphotoxin B
IAGP
MGI
PMID:12115620
NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
IAGP
MGI
PMID:19150426
NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122
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Map3k7
mitogen-activated protein kinase kinase kinase 7
IAGP
MGI
PMID:16940043
NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
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Mark2
MAP/microtubule affinity regulating kinase 2
IAGP
MGI
PMID:11287624
NCBI chr19:7,252,761...7,319,222
Ensembl chr19:7,252,761...7,319,225
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Mdm2
transformed mouse 3T3 cell double minute 2
IAGP
MGI
PMID:20832751
NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
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Mfge8
milk fat globule EGF and factor V/VIII domain containing
IAGP
MGI
PMID:15155946
NCBI chr 7:78,783,516...78,798,808
Ensembl chr 7:78,783,516...78,798,808
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Mir144
microRNA 144
IAGP
MGI
PMID:20679398
NCBI chr11:77,963,831...77,963,896
Ensembl chr11:77,963,831...77,963,896
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Mir451a
microRNA 451a
IAGP
MGI
PMID:20679398
NCBI chr11:77,963,996...77,964,067
Ensembl chr11:77,963,996...77,964,067
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Mt2
metallothionein 2
IAGP
MGI
PMID:10906280
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
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Nckap1l
NCK associated protein 1 like
IAGP
MGI
PMID:19015308
NCBI chr15:103,362,219...103,411,288
Ensembl chr15:103,362,221...103,407,237
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Neu1
neuraminidase 1
IAGP
MGI
PMID:12023988
NCBI chr17:35,150,229...35,156,273
Ensembl chr17:35,150,229...35,154,929
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Nf1
neurofibromin 1
IAGP
MGI
PMID:23412344
NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438
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Olah
oleoyl-ACP hydrolase
IAGP
MGI
PMID:39137778
NCBI chr 2:3,343,019...3,367,964
Ensembl chr 2:3,343,019...3,398,247
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Orai1
ORAI calcium release-activated calcium modulator 1
IAGP
MGI
PMID:28294127
NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519
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Orai2
ORAI calcium release-activated calcium modulator 2
IAGP
MGI
PMID:28294127
NCBI chr 5:136,176,310...136,201,418
Ensembl chr 5:136,176,313...136,199,567
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Pawr
PRKC, apoptosis, WT1, regulator
IAGP
MGI
PMID:12970181
NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101
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Pdcd1
programmed cell death 1
IAGP
MGI
PMID:27410049
NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
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Plcg2
phospholipase C, gamma 2
IAGP
MGI
PMID:16585562
NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881
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Pld4
phospholipase D family member 4
IAGP
MGI
PMID:30679154
NCBI chr12:112,727,089...112,735,420
Ensembl chr12:112,727,089...112,735,424
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Ppia
peptidylprolyl isomerase A
IAGP
MGI
PMID:15308100
NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817
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Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
IAGP
MGI
PMID:11809801
NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892
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Pten
phosphatase and tensin homolog
IAGP
MGI
PMID:16598206
NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
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Ptgs2
prostaglandin-endoperoxide synthase 2
IAGP
MGI
PMID:8521477
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
IAGP
MGI
PMID:9271584
NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IAGP
MGI
PMID:23619366
NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563
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Ptprc
protein tyrosine phosphatase receptor type C
IAGP
MGI
PMID:8666928
NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
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Rad50
RAD50 double strand break repair protein
IAGP
MGI
PMID:12208847
NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146
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Rc3h1
RING CCCH (C3H) domains 1
IAGP
MGI
PMID:21844204
NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548
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Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
IAGP
MGI
PMID:14499111
NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363
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Runx1
runt related transcription factor 1
IAGP
MGI
PMID:19647224
NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
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Sac3d1
SAC3 domain containing 1
IAGP
MGI
PMID:18838617
NCBI chr19:6,166,025...6,168,689
Ensembl chr19:6,166,030...6,168,680
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Sele
selectin, endothelial cell
IAGP
MGI
PMID:8598043
NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
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Sell
selectin, lymphocyte
IAGP
MGI
PMID:14614858 PMID:17182566
NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750
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Selp
selectin, platelet
IAGP
MGI
PMID:8598043
NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
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Sh2b3
SH2B adaptor protein 3
IAGP
MGI
PMID:15705783
NCBI chr 5:121,953,544...121,975,706
Ensembl chr 5:121,953,551...121,975,709
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Sipa1
signal-induced proliferation associated gene 1
IAGP
MGI
PMID:12892713
NCBI chr19:5,701,211...5,713,758
Ensembl chr19:5,701,213...5,713,735
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Slc20a1
solute carrier family 20, member 1
IAGP
MGI
PMID:23190530
NCBI chr 2:129,038,662...129,053,535
Ensembl chr 2:129,040,684...129,053,536
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Spi1
Spi-1 proto-oncogene
IAGP
MGI
PMID:15146183
NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101
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Tank
TRAF family member-associated Nf-kappa B activator
IAGP
MGI
PMID:19668221
NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515
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Tcra
T cell receptor alpha chain
IAGP
MGI
PMID:7991563
NCBI chr14:52,665,424...54,461,655
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Tcrg
T cell receptor gamma chain
IAGP
MGI
PMID:16034115
NCBI chr13:19,362,212...19,540,646
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Tlr7
toll-like receptor 7
IAGP
MGI
PMID:35477763
NCBI chr X:166,086,376...166,113,570
Ensembl chr X:166,087,925...166,113,554
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Tmem35a
transmembrane protein 35A
IAGP
MGI
PMID:27170659
NCBI chr X:133,195,974...133,206,718
Ensembl chr X:133,195,974...133,206,718
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Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
IAGP
MGI
PMID:18455983
NCBI chr 3:95,046,832...95,051,581
Ensembl chr 3:95,046,832...95,049,671
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Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
IAGP
MGI
PMID:10500098
NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709
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Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
IAGP
MGI
PMID:22011580
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
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Tnip1
TNFAIP3 interacting protein 1
IAGP
MGI
PMID:22011580
NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743
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Traf3ip2
TRAF3 interacting protein 2
IAGP
MGI
PMID:22585710 PMID:23123062
NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303
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Trap1
TNF receptor-associated protein 1
IAGP
MGI
PMID:25088416
NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691
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Trp53
transformation related protein 53
IAGP
MGI
PMID:23412344 PMID:23665223
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
G
Ung
uracil DNA glycosylase
IAGP
MGI
PMID:12934097
NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384
G
Vcam1
vascular cell adhesion molecule 1
IAGP
MGI
PMID:15769895
NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
G
Was
Wiskott-Aldrich syndrome
IAGP
MGI
PMID:19805221
NCBI chr X:7,947,705...7,956,730
Ensembl chr X:7,947,692...7,956,737
G
Zfp14
zinc finger protein 14
IAGP
MGI
PMID:36349645
NCBI chr 7:29,735,782...29,751,664
Ensembl chr 7:29,735,784...29,750,805
G
Zfp36
zinc finger protein 36
IAGP
MGI
PMID:8630730
NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
G
Zfp871
zinc finger protein 871
IAGP
MGI
PMID:34257081
NCBI chr17:32,984,470...33,007,261
Ensembl chr17:32,984,470...33,007,261
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all