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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal pituitary gland morphology
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Accession:MP:0000633 term browser browse the term
Definition:any structural anomaly of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin from the anterior lobe; melanocyte stimulating hormone from the intermediate lobe and hormones involved in blood pressure regulation from the posterior lobe
Synonyms:exact_synonym: abnormal hypophysis morphology;   abnormal pituitary morphology
 narrow_synonym: pituitary gland dysplasia
 broad_synonym: abnormal pituitary glands


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abnormal gonadotroph morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
decreased pituitary gland weight term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
increased pituitary gland weight term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP in KO rat RGD PMID:30893315 RGD:126908018 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018
small adenohypophysis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tg thyroglobulin IAGP RGD PMID:11089535 PMID:3366187 RGD:730133, RGD:12880373 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Tgrdw thyroglobulin; rdw mutant IAGP RGD PMID:11089535 PMID:3366187 RGD:730133, RGD:12880373
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5428
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal endocrine gland morphology 164
          abnormal neuroendocrine gland morphology 42
            abnormal pituitary gland morphology 42
              abnormal adenohypophysis morphology + 10
              abnormal neurohypophysis morphology + 0
              abnormal pituitary gland development + 0
              abnormal pituitary gland size + 38
              abnormal pituitary intermediate lobe morphology + 0
              absent pituitary gland 0
              decreased pituitary gland tumor incidence 0
              ectopic pituitary gland 0
              increased pituitary gland tumor incidence + 0
              pituitary gland peliosis + 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5428
    nervous system phenotype 383
      abnormal nervous system morphology 220
        abnormal brain morphology 142
          abnormal forebrain morphology 86
            abnormal diencephalon morphology 45
              abnormal pituitary gland morphology 42
                abnormal adenohypophysis morphology + 10
                abnormal neurohypophysis morphology + 0
                abnormal pituitary gland development + 0
                abnormal pituitary gland size + 38
                abnormal pituitary intermediate lobe morphology + 0
                absent pituitary gland 0
                decreased pituitary gland tumor incidence 0
                ectopic pituitary gland 0
                increased pituitary gland tumor incidence + 0
                pituitary gland peliosis + 0
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