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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal mammary gland morphology
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Accession:MP:0000627 term browser browse the term
Definition:any structural anomaly of the compound, alveolar and apocrine accessory gland of the skin of mammals that secretes milk
Comment:The neonatal male and female rat and mouse have 6 and 5 pairs of glands, respectively, with a single, central lactiferous duct, several branching secondary ducts, and numerous tertiary ducts (Ceriani 1970; Cardiff and Wellings 1999). In the rat, the glands are distributed in pairs along the milk line, with 1 pair cervical, 2 thoracic, 1 abdominal, and 2 inguinal (Astwood, Geschickter, and Rausch 1937). Distribution in the mouse is in the neck, chest wall (2 pairs), abdominal wall, and inguinal region (Cardiff and Wellings 1999).
Synonyms:exact_synonym: abnormal glandula mammaria morphology;   abnormal lactiferous gland morphology;   abnormal mammary glands;   mammary gland dysplasia
 related_synonym: abnormal Brustdruese morphology;   abnormal dug morphology;   abnormal lobe of mammary gland morphology;   abnormal mamma morphology;   abnormal mammae morphology



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abnormal mammary gland alveolus morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edaradd EDAR associated via death domain IAGP DNA:missense mutation:exon:p.Pro153Ser(rat) RGD PMID:22013926 RGD:14398762 NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
JBrowse link
G EdaraddswhKyo EDAR-associated death domain;swh Kyo mutant IAGP DNA:missense mutation:exon:p.Pro153Ser(rat) RGD PMID:22013926 RGD:14398762
abnormal mammary gland development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IMP RGD PMID:16964288 RGD:1599505 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brca2m1Uwm BRCA2, DNA repair associated; mutation 1, University of Wisconsin-Madison IMP RGD PMID:16964288 RGD:1599505
G Esr1 estrogen receptor 1 IMP RGD PMID:24506075 RGD:8552987 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr1em1Soar estrogen receptor 1; ZFN induced mutant 1, Soar IMP RGD PMID:24506075 RGD:8552987
abnormal mammary gland luminal epithelium morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP RGD PMID:30893315 RGD:126908018 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018
mammary gland hypoplasia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edaradd EDAR associated via death domain IAGP in females, compared to heterozygous animals RGD PMID:15829729 RGD:2304219 NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
JBrowse link
G EdaraddswhKyo EDAR-associated death domain;swh Kyo mutant IAGP in females, compared to heterozygous animals RGD PMID:15829729 RGD:2304219

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    integument phenotype 171
      abnormal skin adnexa morphology 169
        abnormal mammary gland morphology 99
          abnormal abdominal mammary gland morphology 0
          abnormal areola morphology 0
          abnormal cervical mammary gland morphology 0
          abnormal inguinal mammary gland morphology 0
          abnormal mammary gland connective tissue morphology 0
          abnormal mammary gland development + 7
          abnormal mammary gland epithelium morphology + 8
          abnormal mammary gland lobule morphology + 3
          abnormal mammary gland number + 0
          abnormal mammary gland stroma morphology 0
          abnormal nipple morphology + 0
          abnormal thoracic mammary gland morphology 0
          decreased mammary gland tumor incidence + 26
          increased mammary gland tumor incidence + 56
          mammary gland hyperplasia 0
          mammary gland hypoplasia 3
          pale mammary gland 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal exocrine gland morphology 119
          abnormal apocrine gland morphology 99
            abnormal mammary gland morphology 99
              abnormal abdominal mammary gland morphology 0
              abnormal areola morphology 0
              abnormal cervical mammary gland morphology 0
              abnormal inguinal mammary gland morphology 0
              abnormal mammary gland connective tissue morphology 0
              abnormal mammary gland development + 7
              abnormal mammary gland epithelium morphology + 8
              abnormal mammary gland lobule morphology + 3
              abnormal mammary gland number + 0
              abnormal mammary gland stroma morphology 0
              abnormal nipple morphology + 0
              abnormal thoracic mammary gland morphology 0
              decreased mammary gland tumor incidence + 26
              increased mammary gland tumor incidence + 56
              mammary gland hyperplasia 0
              mammary gland hypoplasia 3
              pale mammary gland 0
paths to the root