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Pathways

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal mast cell morphology
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Accession:MP:0000359 term browser browse the term
Definition:any structural anomaly of a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation



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abnormal mast cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) IAGP MGI PMID:19966810 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
JBrowse link
G Chst15 carbohydrate sulfotransferase 15 IAGP MGI PMID:20439988 NCBI chr 7:131,837,508...131,919,227
Ensembl chr 7:131,837,509...131,918,957
JBrowse link
G Cpa3 carboxypeptidase A3, mast cell IAGP MGI PMID:15988029 NCBI chr 3:20,269,780...20,296,373
Ensembl chr 3:20,269,784...20,296,345
JBrowse link
G Dsg4 desmoglein 4 IAGP MGI PMID:18677469 NCBI chr18:20,569,234...20,606,191
Ensembl chr18:20,569,232...20,604,878
JBrowse link
G Fas Fas cell surface death receptor IAGP MGI PMID:18677469 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IAGP MGI PMID:25843682 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:25843682 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Hdc histidine decarboxylase IAGP MGI PMID:11478947 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Il5 interleukin 5 IAGP MGI PMID:12150887 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il9 interleukin 9 IAGP MGI PMID:11070175 PMID:12150887 NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059
JBrowse link
G Lmo2 LIM domain only 2 IAGP MGI PMID:19966810 NCBI chr 2:103,788,340...103,812,223
Ensembl chr 2:103,788,331...103,812,223
JBrowse link
G Mcpt1 mast cell protease 1 IAGP MGI PMID:9708809 NCBI chr14:56,255,421...56,257,848
Ensembl chr14:56,255,428...56,257,841
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IAGP MGI PMID:10466727 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630
JBrowse link
G Pla2g3 phospholipase A2, group III IAGP MGI PMID:23624557 NCBI chr11:3,438,158...3,449,346
Ensembl chr11:3,438,284...3,449,350
JBrowse link
G Prss57 serine protease 57 IAGP MGI PMID:33214666 NCBI chr10:79,617,308...79,630,523
Ensembl chr10:79,617,308...79,626,795
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 IAGP MGI PMID:15235600 NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183
JBrowse link
G Smim3 small integral membrane protein 3 IAGP MGI PMID:19966810 NCBI chr18:60,607,263...60,635,055
Ensembl chr18:60,607,263...60,635,059
JBrowse link
G Srgn serglycin IAGP MGI PMID:15231821 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230
JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:15947484 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:9492006 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
G Was Wiskott-Aldrich syndrome IAGP MGI PMID:14645152 NCBI chr  X:7,947,705...7,956,730
Ensembl chr  X:7,947,692...7,956,737
JBrowse link
abnormal dermal mast cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyst lysosomal trafficking regulator IAGP MGI PMID:16518687 NCBI chr13:13,764,896...13,953,388
Ensembl chr13:13,764,982...13,953,388
JBrowse link
G Ptgdr prostaglandin D receptor IAGP MGI PMID:23624557 NCBI chr14:45,088,692...45,096,832
Ensembl chr14:45,088,692...45,096,832
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) IAGP MGI PMID:23624557 NCBI chr 2:25,356,721...25,360,141
Ensembl chr 2:25,356,721...25,360,058
JBrowse link
abnormal mast cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Commd10 COMM domain containing 10 IAGP MGI PMID:24204913 NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351
JBrowse link
G Gab2 growth factor receptor bound protein 2-associated protein 2 IAGP MGI PMID:11861309 NCBI chr 7:96,730,958...96,958,158
Ensembl chr 7:96,730,793...96,958,153
JBrowse link
G Mcemp1 mast cell expressed membrane protein 1 IAGP MGI PMID:37041174 NCBI chr 8:3,715,754...3,718,916
Ensembl chr 8:3,715,754...3,719,259
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IAGP MGI PMID:19109198 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630
JBrowse link
G Patz1 POZ (BTB) and AT hook containing zinc finger 1 IAGP MGI PMID:24204913 NCBI chr11:3,239,131...3,259,083
Ensembl chr11:3,238,874...3,259,083
JBrowse link
G Pla2g3 phospholipase A2, group III IAGP MGI PMID:23624557 NCBI chr11:3,438,158...3,449,346
Ensembl chr11:3,438,284...3,449,350
JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) IAGP MGI PMID:10220374 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041
JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:12714518 PMID:15947484 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IAGP MGI PMID:12714518 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Tpsab1 tryptase alpha/beta 1 IAGP MGI PMID:19109198 NCBI chr17:25,562,219...25,564,536
Ensembl chr17:25,562,219...25,564,536
JBrowse link
G Tpsb2 tryptase beta 2 IAGP MGI PMID:19109198 NCBI chr17:25,585,282...25,587,070
Ensembl chr17:25,585,279...25,588,072
JBrowse link
absent mast cells term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpa3 carboxypeptidase A3, mast cell IAGP MGI PMID:22101159 PMID:25843682 NCBI chr 3:20,269,780...20,296,373
Ensembl chr 3:20,269,784...20,296,345
JBrowse link
G Fbn1 fibrillin 1 IAGP MGI PMID:7704626 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IAGP MGI PMID:25843682 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:25843682 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IAGP MGI PMID:7704626 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:12714518 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IAGP MGI PMID:12714518 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
cutaneous mastocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 IAGP MGI PMID:29649548 NCBI chr10:61,032,886...61,109,447
Ensembl chr10:61,032,891...61,109,217
JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 IAGP MGI PMID:29649548 NCBI chr11:50,492,912...50,698,400
Ensembl chr11:50,492,911...50,698,400
JBrowse link
G Ctnnb1 catenin beta 1 IAGP MGI PMID:24315444 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Dsg3 desmoglein 3 IAGP MGI PMID:8182278 NCBI chr18:20,643,331...20,674,367
Ensembl chr18:20,643,331...20,680,516
JBrowse link
G Krt14 keratin 14 IAGP MGI PMID:23918954 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 IAGP MGI PMID:15235600 NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183
JBrowse link
G Sharpin SHANK-associated RH domain interacting protein IAGP MGI PMID:8362989 PMID:8774148 NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311
JBrowse link
G Wls wntless WNT ligand secretion mediator IAGP MGI PMID:23918954 PMID:24315444 NCBI chr 3:159,545,287...159,644,302
Ensembl chr 3:159,545,309...159,644,300
JBrowse link
decreased mast cell histamine storage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 antigen IAGP MGI PMID:19204665 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Hdc histidine decarboxylase IAGP MGI PMID:11478947 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IAGP MGI PMID:10466726 PMID:10466727 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630
JBrowse link
G Prss57 serine protease 57 IAGP MGI PMID:33214666 NCBI chr10:79,617,308...79,630,523
Ensembl chr10:79,617,308...79,626,795
JBrowse link
G Ptgdr prostaglandin D receptor IAGP MGI PMID:23624557 NCBI chr14:45,088,692...45,096,832
Ensembl chr14:45,088,692...45,096,832
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) IAGP MGI PMID:23624557 NCBI chr 2:25,356,721...25,360,141
Ensembl chr 2:25,356,721...25,360,058
JBrowse link
decreased mast cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 IAGP MGI PMID:9367154 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 IAGP MGI PMID:15517609 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
JBrowse link
G Cd44 CD44 antigen IAGP MGI PMID:19204665 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Gab2 growth factor receptor bound protein 2-associated protein 2 IAGP MGI PMID:11449275 PMID:11861309 PMID:21653832 NCBI chr 7:96,730,958...96,958,158
Ensembl chr 7:96,730,793...96,958,153
JBrowse link
G Hdc histidine decarboxylase IAGP MGI PMID:11478947 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Itgb7 integrin beta 7 IAGP MGI PMID:10898502 NCBI chr15:102,124,429...102,141,840
Ensembl chr15:102,124,430...102,140,379
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IAGP MGI PMID:7683920 PMID:8605335 PMID:10716931 PMID:15024050 PMID:15067126 More... NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Kitl kit ligand IAGP MGI PMID:367470 PMID:8605335 PMID:9751763 PMID:19874813 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 IAGP MGI PMID:16640660 NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 IAGP MGI PMID:22001390 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mitf melanogenesis associated transcription factor IAGP MGI PMID:6127714 NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IAGP MGI PMID:10466727 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630
JBrowse link
G Nfatc2ip nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein IAGP MGI PMID:20133688 NCBI chr 7:125,982,025...125,995,909
Ensembl chr 7:125,982,026...125,995,909
JBrowse link
G Sele selectin, endothelial cell IAGP MGI PMID:17456770 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Selp selectin, platelet IAGP MGI PMID:17456770 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Srgn serglycin IAGP MGI PMID:15231821 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230
JBrowse link
G Stat5a signal transducer and activator of transcription 5A IAGP MGI PMID:15947484 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
decreased mast cell protease storage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase IAGP MGI PMID:11478947 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IAGP MGI PMID:10466726 PMID:10466727 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630
JBrowse link
increased mast cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adtrp androgen dependent TFPI regulating protein IAGP MGI PMID:30571485 NCBI chr13:41,916,621...42,001,092
Ensembl chr13:41,916,624...42,001,160
JBrowse link
G Agr2 anterior gradient 2 IAGP MGI PMID:19359471 NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086
JBrowse link
G Apc APC, WNT signaling pathway regulator IAGP MGI PMID:18077429 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605
JBrowse link
G Casp8 caspase 8 IAGP MGI PMID:21135236 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 IAGP MGI PMID:25692702 NCBI chr10:24,649,712...24,712,093
Ensembl chr10:24,648,304...24,718,721
JBrowse link
G Fbn1 fibrillin 1 IAGP MGI PMID:4048170 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IAGP MGI PMID:25843682 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:25843682 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Il4 interleukin 4 IAGP MGI PMID:20512127 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IAGP MGI PMID:12754375 PMID:22652566 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Kitl kit ligand IAGP MGI PMID:7533739 PMID:19874813 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IAGP MGI PMID:20512127 NCBI chr 4:3,676,865...3,791,612
Ensembl chr 4:3,678,115...3,813,122
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 IAGP MGI PMID:25692702 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Runx1 runt related transcription factor 1 IAGP MGI PMID:16247465 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
JBrowse link
G Sele selectin, endothelial cell IAGP MGI PMID:17456770 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IAGP MGI PMID:21668589 NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16532
    hematopoietic system phenotype 5355
      abnormal hematopoietic system morphology/development 4896
        abnormal hematopoietic cell morphology 4074
          abnormal blood cell morphology 3056
            abnormal granulocyte morphology 885
              abnormal mast cell morphology 64
                abnormal dermal mast cell morphology 3
                abnormal mast cell differentiation 11
                abnormal mast cell number + 42
                decreased mast cell histamine storage 6
                decreased mast cell protease storage 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 16532
    immune system phenotype 5526
      abnormal immune system morphology 3944
        abnormal immune system cell morphology 2743
          abnormal leukocyte morphology 2722
            abnormal myeloid leukocyte morphology 1400
              abnormal granulocyte morphology 885
                abnormal mast cell morphology 64
                  abnormal dermal mast cell morphology 3
                  abnormal mast cell differentiation 11
                  abnormal mast cell number + 42
                  decreased mast cell histamine storage 6
                  decreased mast cell protease storage 2
paths to the root