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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal systemic arterial blood pressure
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Accession:MP:0000230 term browser browse the term
Definition:altered tension of the blood within the systemic arteries
Synonyms:exact_synonym: heart/cardiovascular system: blood pressure anomalies
 alt_id: MP:0001594;   MP:0002129
 xref: MGI:2173589


show annotations for term's descendants           Sort by:
decreased mean systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 IMP compared to wild type RGD PMID:32306766 RGD:155598602 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Bmal1em1Mcwi basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi IMP compared to wild type RGD PMID:32306766 RGD:155598602
G Cd247 Cd247 molecule induced IMP compared to wild-type RGD PMID:24343121 PMID:24343121 RGD:13442481, RGD:13442481 NCBI chr13:80,576,264...80,651,422
Ensembl chr13:80,576,202...80,655,248 		JBrowse link
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin induced IMP compared to wild-type RGD PMID:24343121 PMID:24343121 RGD:13442481, RGD:13442481
G Cd36 CD36 molecule IMP RGD PMID:22128087 RGD:6893560 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Clcn6 chloride voltage-gated channel 6 IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,715,593...163,748,301
Ensembl chr 5:163,717,439...163,748,198 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gper1em1Bj G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:24935944 RGD:14985214 NCBI chr12:40,001,205...40,030,671
Ensembl chr12:40,001,498...40,042,020 		JBrowse link
G Mc4r melanocortin 4 receptor IMP RGD PMID:24400148 RGD:13825242 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:24400148 RGD:13825242
G Nox4 NADPH oxidase 4 induced IMP compared to SS/JrHsdMcwi RGD PMID:26644237 PMID:26644237 RGD:11085830, RGD:11085830 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nox4em2Mcwi NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin induced IMP compared to SS/JrHsdMcwi RGD PMID:26644237 PMID:26644237 RGD:11085830, RGD:11085830
G P2rx7 purinergic receptor P2X 7 IMP RGD PMID:31630543 RGD:14995937 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
G Ren renin sexual_dimorphism IMP compared to wild type
compared to wild type male 		RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Renem1Mcwi renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin sexual_dimorphism IMP compared to wild type
compared to wild type male 		RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614
decreased pulse pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gper1em1Bj G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000
decreased susceptibility to hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 IMP RGD PMID:23753405 RGD:13782272 NCBI chr 8:39,014,822...39,066,716
Ensembl chr 8:39,037,992...39,066,715 		JBrowse link
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu IMP RGD PMID:23753405 RGD:13782272
G Ncf2 neutrophil cytosolic factor 2 induces IMP compared to wild-type littermates RGD PMID:22326221 PMID:22326221 RGD:9587793, RGD:9587793 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149 		JBrowse link
G Ncf2em1Mcwi neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi induces IMP compared to wild-type littermates RGD PMID:22326221 PMID:22326221 RGD:9587793, RGD:9587793
G Nox4 NADPH oxidase 4 induced IMP compared to SS/JrHsdMcwi RGD PMID:26644237 PMID:26644237 RGD:11085830, RGD:11085830 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nox4em2Mcwi NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin induced IMP compared to SS/JrHsdMcwi RGD PMID:26644237 PMID:26644237 RGD:11085830, RGD:11085830
G Plekha7 pleckstrin homology domain containing A7 IMP compared to wild type RGD PMID:25136115 PMID:25136115 RGD:11079199, RGD:11079199 NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:179,799,040...179,982,281 		JBrowse link
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin IMP compared to wild type RGD PMID:25136115 PMID:25136115 RGD:11079199, RGD:11079199
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:40,391,755...40,414,336
Ensembl chr12:40,392,633...40,414,335 		JBrowse link
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25776069 RGD:13442483
decreased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 IAGP DNA:polymorphism RGD PMID:19423552 RGD:2312639 NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:34,258,899...34,388,952 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:12215473 RGD:1580453 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:24935944 RGD:14985214 NCBI chr12:40,001,205...40,030,671
Ensembl chr12:40,001,498...40,042,020 		JBrowse link
G Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 IMP compared to SS/JrHsdMcwi RGD PMID:28931751 RGD:38500204 NCBI chr10:96,489,329...96,520,745
Ensembl chr10:96,460,331...96,566,075 		JBrowse link
G Kcnj16em1Mcwi potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP compared to SS/JrHsdMcwi RGD PMID:28931751 RGD:38500204
decreased systemic arterial diastolic blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 IMP As compared to SS parents RGD PMID:23185005 RGD:9685162 NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:34,258,899...34,388,952 		JBrowse link
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj IMP As compared to SS parents RGD PMID:23185005 RGD:9685162
G Bmal1 basic helix-loop-helix ARNT like 1 IMP compared to wild type RGD PMID:32306766 RGD:155598602 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Bmal1em1Mcwi basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi IMP compared to wild type RGD PMID:32306766 RGD:155598602
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IMP RGD PMID:31327268 RGD:18899561 NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058 		JBrowse link
G Camk2n1em1Tja calcium/calmodulin-dependent protein kinase II inhibitor 1; ZFN induced mutant 1, Tja IMP RGD PMID:31327268 RGD:18899561
G Clcn6 chloride voltage-gated channel 6 IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,715,593...163,748,301
Ensembl chr 5:163,717,439...163,748,198 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gper1em1Bj G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
G Ren renin sexual_dimorphism IMP compared to wild type
compared to wild type male 		RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Renem1Mcwi renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin sexual_dimorphism IMP compared to wild type male RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614
decreased systemic arterial systolic blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 IMP As compared to SS parents RGD PMID:23185005 RGD:9685162 NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:34,258,899...34,388,952 		JBrowse link
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj IMP As compared to SS parents RGD PMID:23185005 RGD:9685162
G Bmal1 basic helix-loop-helix ARNT like 1 IMP compared to wild type RGD PMID:32306766 RGD:155598602 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Bmal1em1Mcwi basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi IMP compared to wild type RGD PMID:32306766 RGD:155598602
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IMP RGD PMID:31327268 RGD:18899561 NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:155,957,878...155,961,058 		JBrowse link
G Camk2n1em1Tja calcium/calmodulin-dependent protein kinase II inhibitor 1; ZFN induced mutant 1, Tja IMP RGD PMID:31327268 RGD:18899561
G Cfb complement factor B IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Cfbem1Tja complement factor B, ZFN induced mutant 1, Tja IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403
G Gper1 G protein-coupled estrogen receptor 1 IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gper1em1Bj G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to female wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
G Ren renin sexual_dimorphism IMP compared to wild type
compared to wild type male 		RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Renem1Mcwi renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin sexual_dimorphism IMP compared to wild type male RGD PMID:21242461 PMID:21242461 RGD:7771614, RGD:7771614
hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor IMP
IAGP 		DNA:mutations:cds: : (rat) RGD PMID:27465994 PMID:30278832 RGD:12911217, RGD:401960095 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Nppb natriuretic peptide B IMP RGD PMID:26063669 RGD:12910116 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Nppbem2Mcwi natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26063669 RGD:12910116
increased mean systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alms1 ALMS1, centrosome and basal body associated protein exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229 NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:119,683,076...119,783,471 		JBrowse link
G Alms1em1Mcwi Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229
G Lepr leptin receptor IAGP DNA:mutations:cds: : (rat) RGD PMID:32710530 RGD:401960103 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Nppa natriuretic peptide A IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Rag1 recombination activating 1 IMP on 4% NaCl diet RGD PMID:23364523 RGD:7207429 NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:108,371,978...108,383,261 		JBrowse link
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP on 4% NaCl diet RGD PMID:23364523 RGD:7207429
G Rag1em2Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP on 4% NaCl diet RGD PMID:23364523 RGD:7207429
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
G Sod3 superoxide dismutase 3 onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sod3m1Mcwi superoxide dismutase 3; mutation 1, Medical College of Wisconsin onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712
G Tmem67 transmembrane protein 67 IAGP RGD PMID:11095650 RGD:1300514 NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:30,333,793...30,386,666 		JBrowse link
G Tmem67wpk transmembrane protein 67; wpk mutant IAGP RGD PMID:11095650 RGD:1300514
G Tph2 tryptophan hydroxylase 2 sexual_dimorphism IMP RGD PMID:32909922 PMID:36169206 RGD:597830145, RGD:597830153 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639 		JBrowse link
increased pulse pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E IMP RGD PMID:29166645 RGD:150520219 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Apoeem1Ejt apolipoprotein E; TALEN induced mutant 1, Ejt IMP RGD PMID:29166645 RGD:150520219
G Apoeem1Sage apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:29166645 RGD:150520219
G Ddx52 DExD-box helicase 52 IAGP DNA:polymorphism RGD PMID:17218081 RGD:1599269 NCBI chr10:69,322,062...69,344,856
Ensembl chr10:69,322,114...69,428,714 		JBrowse link
G Ednrb endothelin receptor type B IDA RGD PMID:16179487 RGD:1581856 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor IDA RGD PMID:12093887 RGD:625448 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 IDA RGD PMID:14551242 RGD:1298970 NCBI chr10:19,062,014...19,119,005
Ensembl chr10:19,062,291...19,073,204 		JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP RGD PMID:7629399 RGD:1357231 NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:178,231,766...178,247,088 		JBrowse link
G Ren renin IAGP RGD PMID:8567976 RGD:61046 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Tnf tumor necrosis factor IAGP RGD PMID:9590569 RGD:1357163 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
increased systemic arterial diastolic blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP RGD PMID:12511524 RGD:628585 NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:178,231,766...178,247,088 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP RGD PMID:29906243 RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP RGD PMID:29906243 RGD:38596340
G Sod3 superoxide dismutase 3 onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sod3m1Mcwi superoxide dismutase 3; mutation 1, Medical College of Wisconsin onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712
increased systemic arterial systolic blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 IAGP RGD PMID:15474463 RGD:1302895 NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732 		JBrowse link
G Adora2b adenosine A2B receptor IMP RGD PMID:26385692 RGD:11533328 NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091 		JBrowse link
G Adora2bem2Mcwi adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26385692 RGD:11533328
G Alms1 ALMS1, centrosome and basal body associated protein exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229 NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:119,683,076...119,783,471 		JBrowse link
G Alms1em1Mcwi Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IAGP RGD PMID:7981756 RGD:69709 NCBI chr 7:108,653,385...108,660,062
Ensembl chr 7:108,653,378...108,660,995
Ensembl chr 7:108,653,378...108,660,995 		JBrowse link
G Ednra endothelin receptor type A IDA RGD PMID:16157796 RGD:1581830 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IAGP DNA:duplication RGD PMID:20231529 RGD:11251783 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IAGP DNA:deletion:exon (rat) RGD PMID:16368876 RGD:1581602 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072 		JBrowse link
G Kcnq1dfk potassium voltage-gated channel subfamily Q member 1;deafness Kyoto IAGP RGD PMID:16368876 RGD:1581602
G Lepr leptin receptor treatment
onset 		IAGP
IMP 		compared to treated
compared to SS/JrHsdMcwi 		RGD PMID:23154293 PMID:33568522 PMID:27465994 RGD:13432147, RGD:401965412, RGD:12911217 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin onset IMP compared to SS/JrHsdMcwi RGD PMID:27465994 RGD:12911217
G Leprfa leptin receptor; fa mutant IAGP RGD PMID:23154293 RGD:13432147
G Nppa natriuretic peptide A IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 IMP as compared to the wild-type RGD PMID:24006081 RGD:8662415 NCBI chr 5:163,623,847...163,650,737
Ensembl chr 5:163,623,848...163,651,110 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rarres2em1Msu retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu sexual_dimorphism IMP compared to male wild-type RGD PMID:29906243 PMID:29906243 RGD:38596340, RGD:38596340
G Sod3 superoxide dismutase 3 onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sod3m1Mcwi superoxide dismutase 3; mutation 1, Medical College of Wisconsin onset IMP compared to SS/JrHsdMcwi RGD PMID:31972339 RGD:150573712
salt-sensitive hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alms1 ALMS1, centrosome and basal body associated protein exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229 NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:119,683,076...119,783,471 		JBrowse link
G Alms1em1Mcwi Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin exacerbates IMP compared to wild type RGD PMID:30385718 RGD:151361229
G Astn1 astrotactin 1 IMP RGD PMID:24714719 RGD:12792227 NCBI chr13:73,070,754...73,388,902
Ensembl chr13:73,071,267...73,388,895 		JBrowse link
G Brinp2 BMP/retinoic acid inducible neural specific 2 IMP RGD PMID:24714719 RGD:12792227 NCBI chr13:72,964,498...73,065,312
Ensembl chr13:72,964,502...73,065,294 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 IAGP RGD PMID:23817491 RGD:12802368 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Cd247 Cd247 molecule severity IMP RGD PMID:24343121 RGD:13442481 NCBI chr13:80,576,264...80,651,422
Ensembl chr13:80,576,202...80,655,248 		JBrowse link
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin severity IMP RGD PMID:24343121 RGD:13442481
G Chi3l1 chitinase 3 like 1 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825 		JBrowse link
G Chit1 chitinase 1 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:48,117,886...48,165,645
Ensembl chr13:48,145,893...48,165,639 		JBrowse link
G Cop1 COP1, E3 ubiquitin ligase IMP RGD PMID:24714719 RGD:12792227 NCBI chr13:73,954,058...74,095,283
Ensembl chr13:73,963,145...74,095,269 		JBrowse link
G Etnk2 ethanolamine kinase 2 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:47,362,964...47,381,100
Ensembl chr13:47,363,060...47,381,100 		JBrowse link
G Fmod fibromodulin IAGP RGD PMID:23817491 RGD:12802368 NCBI chr13:48,045,567...48,056,184
Ensembl chr13:47,990,774...48,056,183 		JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:49,150,355...49,157,204
Ensembl chr13:49,150,359...49,157,204 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IMP RGD PMID:26077568 RGD:13800514 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd11b2em1Jmul hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul IMP RGD PMID:26077568 RGD:13800514
G Ipo9 importin 9 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:49,362,244...49,414,477
Ensembl chr13:49,365,716...49,414,477 		JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 IMP RGD PMID:23753405 RGD:13782272 NCBI chr 8:39,014,822...39,066,716
Ensembl chr 8:39,037,992...39,066,715 		JBrowse link
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu IMP RGD PMID:23753405 RGD:13782272
G Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:48,976,193...49,095,870
Ensembl chr13:48,976,193...49,095,857 		JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase IAGP RGD PMID:21257920 RGD:12798539 NCBI chr13:41,228,327...41,516,462
Ensembl chr13:41,228,360...41,516,461 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ameliorates IMP RGD PMID:37423509 RGD:597805897 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mmp9em6Mcwi matrix metallopeptidase 9; CRISPR/Cas9 system induced mutant 6, Medical College of Wisconsin ameliorates IMP RGD PMID:37423509 RGD:597805897
G Mybph myosin binding protein H IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:48,205,162...48,212,928
Ensembl chr13:48,205,269...48,212,928 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ameliorates IMP compared to wild-type littermates RGD PMID:22326221 RGD:9587793 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149 		JBrowse link
G Ncf2em1Mcwi neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi ameliorates IMP compared to wild-type littermates RGD PMID:22326221 RGD:9587793
G Nckap5 NCK-associated protein 5 IAGP RGD PMID:21257920 RGD:12798539 NCBI chr13:39,922,576...40,835,849
Ensembl chr13:39,922,737...40,835,521 		JBrowse link
G Nox4 NADPH oxidase 4 severity IMP RGD PMID:26644237 RGD:11085830 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Optc opticin IAGP RGD PMID:23817491 RGD:12802368 NCBI chr13:47,906,145...47,920,334
Ensembl chr13:47,906,197...47,917,416 		JBrowse link
G Pappa2 pappalysin 2 IMP RGD PMID:24714719 RGD:12792227 NCBI chr13:73,407,385...73,683,699
Ensembl chr13:73,407,385...73,681,568 		JBrowse link
G Plekha6 pleckstrin homology domain containing A6 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:47,166,899...47,307,003
Ensembl chr13:47,167,160...47,307,003 		JBrowse link
G Plekha7 pleckstrin homology domain containing A7 ameliorates IMP compared to wild type RGD PMID:25136115 RGD:11079199 NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:179,799,040...179,982,281 		JBrowse link
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin ameliorates IMP compared to wild type RGD PMID:25136115 RGD:11079199
G Prelp proline and arginine rich end leucine rich repeat protein IAGP RGD PMID:23817491 RGD:12802368 NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324 		JBrowse link
G Psme2-ps1 proteasome activator subunit 2, pseudogene 1 IAGP RGD PMID:21257920 RGD:12798539 NCBI chr13:40,742,081...40,742,929 JBrowse link
G Ptprv protein tyrosine phosphatase, receptor type, V IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:49,099,922...49,120,247
Ensembl chr13:49,099,925...49,120,121 		JBrowse link
G Ren renin IAGP RGD PMID:23817491 RGD:12802368 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Resp18 regulated endocrine-specific protein 18 IMP RGD PMID:29570433 RGD:14348960 NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:84,213,467...84,221,299 		JBrowse link
G Resp18em2Mcwi regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:29570433 RGD:14348960
G Rnpep arginyl aminopeptidase IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799 		JBrowse link
G Sox13 SRY-box transcription factor 13 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:47,383,145...47,427,572
Ensembl chr13:47,383,145...47,435,663 		JBrowse link
G Syt2 synaptotagmin 2 IAGP RGD PMID:23460292 RGD:12802369 NCBI chr13:48,639,634...48,749,814
Ensembl chr13:48,639,934...48,749,812 		JBrowse link
G Tmem163 transmembrane protein 163 IAGP RGD PMID:21257920 RGD:12798539 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:41,520,359...41,693,938 		JBrowse link
G Tnr tenascin R IMP RGD PMID:24714719 RGD:12792227 NCBI chr13:74,285,141...74,706,174
Ensembl chr13:74,507,366...74,701,115 		JBrowse link
G Tuba1c-ps1 tubulin, alpha 1C, pseudogene 1 IAGP RGD PMID:21257920 RGD:12798539 NCBI chr13:41,060,047...41,061,387 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    cardiovascular system phenotype 1374
      abnormal cardiovascular system physiology 1152
        abnormal systemic arterial blood pressure 998
          abnormal pulse pressure + 24
          decreased systemic arterial blood pressure + 392
          increased systemic arterial blood pressure + 639
paths to the root