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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal triglyceride level
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Accession:MP:0000187 term browser browse the term
Definition:any anomaly in the concentration of triglyceride, a glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue
Synonyms:exact_synonym: abnormal triacylglycerol level
 alt_id: MP:0001551


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decreased circulating triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl8 angiopoietin-like 8 induces IMP compared to wild type rats RGD PMID:30042156 PMID:30042156 RGD:38549347, RGD:38549347 NCBI chr 8:28,652,555...28,654,581
Ensembl chr 8:20,376,462...20,378,490 		JBrowse link
G Angptl8em1Kyo angiopoietin-like 8; CRISPR/Cas9 induced mutant 1, Kyo induces IMP compared to wild type rats RGD PMID:30042156 PMID:30042156 RGD:38549347, RGD:38549347
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
G Htr7 5-hydroxytryptamine receptor 7 IMP in male RGD PMID:31125290 RGD:14696717 NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Htr7em1Msu 5-hydroxytryptamine receptor 7; CRISPR/Cas9 induced mutant 1, Msu IMP in male RGD PMID:31125290 RGD:14696717
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:23799078 RGD:13462048 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:23799078 RGD:13462048
G Zbtb16 zinc finger and BTB domain containing 16 IMP compared to wild type SHR/OlaIpcv; RGD PMID:28396530 RGD:150340623 NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
G Zbtb16em1Ipcv zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv IMP compared to wild type SHR/OlaIpcv; RGD PMID:28396530 RGD:150340623
decreased circulating VLDL triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl8 angiopoietin-like 8 IMP compared to wild type rats RGD PMID:30042156 RGD:38549347 NCBI chr 8:28,652,555...28,654,581
Ensembl chr 8:20,376,462...20,378,490 		JBrowse link
G Angptl8em1Kyo angiopoietin-like 8; CRISPR/Cas9 induced mutant 1, Kyo IMP compared to wild type rats RGD PMID:30042156 RGD:38549347
decreased liver triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb16 zinc finger and BTB domain containing 16 IMP compared to wild type SHR/OlaIpcv; RGD PMID:28396530 RGD:150340623 NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
G Zbtb16em1Ipcv zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv IMP compared to wild type SHR/OlaIpcv; RGD PMID:28396530 RGD:150340623
decreased triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfb complement factor B IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfbem1Tja complement factor B, ZFN induced mutant 1, Tja IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403
increased circulating triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin IMP RGD PMID:25934999 RGD:11085488 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo IMP RGD PMID:25934999 RGD:11085488
G Gck glucokinase IDA overexpression sufficient to lower blood glucose significantly increased circulating FFA and TG levels (p<0.05) RGD PMID:10512368 RGD:2301945 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:187,179,668...187,181,284
Ensembl chr 2:184,490,840...184,492,456 		JBrowse link
G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989
G Lep leptin IMP DNA:nonsense mutation:cds: RGD PMID:23800849 RGD:8549777 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepm1Kyo leptin; ENU induced mutant1, Kyo IMP RGD PMID:23800849 RGD:8549777
G Lepr leptin receptor treatment
disease_progression		 IMP
IAGP		 compared to ad lib fed rats RGD PMID:27225180 PMID:11500530 PMID:27465994 PMID:26537785 RGD:12910507, RGD:628581, RGD:12911217, RGD:12911216 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin disease_progression IMP RGD PMID:27465994 RGD:12911217
G Leprem3 leptin receptor; TALEN induced mutant 3 IMP RGD PMID:27225180 RGD:12910507
G Leprem4Lizh leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh IMP compared to wild type littermate RGD PMID:26537785 RGD:12911216
G Leprfa leptin receptor; fa mutant treatment IAGP compared to ad lib fed rats RGD PMID:11500530 RGD:628581
G Mc4r melanocortin 4 receptor IMP RGD PMID:24400148 RGD:13825242 NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:24400148 RGD:13825242
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 IMP compared to FHH RGD PMID:24722447 RGD:12910103 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a1m1Mcwi nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin IMP compared to FHH RGD PMID:24722447 RGD:12910103
increased liver triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase copper transporting beta IAGP RGD PMID:17303181 RGD:2292672 NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Atp7bhts ATPase copper transporting beta; hepatitis IAGP RGD PMID:17303181 RGD:2292672
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin IMP RGD PMID:25934999 RGD:11085488 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo IMP RGD PMID:25934999 RGD:11085488
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 induces IMP compared to wild type RGD PMID:29656108 RGD:150520032 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp2j4em1Sage cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage induces IMP compared to wild type RGD PMID:29656108 RGD:150520032
G Ldlr low density lipoprotein receptor IMP RGD PMID:28469073 RGD:12910100 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage IMP RGD PMID:28469073 RGD:12910100
G Lep leptin IMP DNA:nonsense mutation:cds: RGD PMID:23800849 RGD:8549777 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepm1Kyo leptin; ENU induced mutant1, Kyo IMP RGD PMID:23800849 RGD:8549777
G Pparg peroxisome proliferator-activated receptor gamma IAGP RGD PMID:27381370 RGD:127285618 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargm1Kyo peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo IAGP RGD PMID:27381370 RGD:127285618
increased triglyceride level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor IAGP DNA:mutations:cds: : (rat) RGD PMID:30278832 PMID:10901178 PMID:28746409 RGD:401960095, RGD:401965414, RGD:401965413 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5428
    homeostasis/metabolism phenotype 1429
      abnormal homeostasis 1330
        abnormal lipid homeostasis 364
          abnormal lipid level 359
            abnormal triglyceride level 147
              abnormal circulating triglyceride level + 124
              abnormal liver triglyceride level + 24
              abnormal muscle triglyceride level + 0
              decreased triglyceride level + 38
              increased triglyceride level + 110
paths to the root