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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal microglial cell morphology
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Accession:MP:0000136 term browser browse the term
Definition:any structural anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques



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abnormal microglial cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
decreased microglial cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:30249809 PMID:33450391 RGD:41404725, RGD:126781687 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf1rtm(EGFP)Tset colony stimulating factor 1 receptor; target mutant, Tset IMP RGD PMID:33450391 PMID:30249809 RGD:126781687, RGD:41404725
microgliosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
G Slc9a6 solute carrier family 9 member A6 IMP RGD PMID:34928329 RGD:151664747 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375
JBrowse link
G Slc9a6 em1Moro solute carrier family 9 member A6;CRISPR/Cas9 induced mutant1, Moro IMP RGD PMID:34928329 RGD:151664747

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5402
    nervous system phenotype 368
      abnormal nervous system morphology 215
        abnormal glial cell morphology 28
          abnormal CNS glial cell morphology 27
            abnormal microglial cell morphology 14
              abnormal microglial cell differentiation 0
              decreased microglial cell number 7
              microgliosis 10
Path 2
Term Annotations click to browse term
  mammalian phenotype 5402
    hematopoietic system phenotype 250
      abnormal hematopoietic system morphology/development 230
        abnormal hematopoietic cell morphology 186
          abnormal myeloid cell morphology 108
            abnormal myeloid leukocyte morphology 70
              abnormal phagocyte morphology 47
                abnormal mononuclear phagocyte morphology 42
                  abnormal macrophage morphology 36
                    abnormal microglial cell morphology 14
                      abnormal microglial cell differentiation 0
                      decreased microglial cell number 7
                      microgliosis 10
paths to the root