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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Schwannoma
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Accession:HP:0100008 term browser browse the term
Definition:A benign nerve sheath tumor composed of Schwann cells.
Comment:Glial cells are cells that support nerve cells. Schwann cells wrap around the axon to form the myelin sheath. Schwann cells are involved in many important aspects of peripheral nerve biology; the conduction of nervous impulses along axons, nerve development and regeneration, trophic support for neurons, production of the nerve extracellular matrix and presentation of antigens to T-lymphocytes. Charcot-Marie-Tooth disease (CMT), Guillain-Barre syndrome (GBS), schwannomatosis and chronic inflammatory demyelinating polyneuropathy (CIDP) are all neuropathies involving Schwann cells.
Synonyms:exact_synonym: Neurilemmoma;   Neurinoma;   Neurolemmoma;   Schwann cell tumor;   Schwann cell tumour
 related_synonym: SCHWANNOMAS
 xref: SNOMEDCT_US:404022001;   SNOMEDCT_US:985004;   UMLS:C0027809


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Abnormal peripheral nervous system morphology 0
            Neoplasm of the peripheral nervous system 0
              Schwannoma 0
                Peripheral schwannoma 0
                Scleral schwannoma 0
                Vestibular schwannoma + 0
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