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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Pituitary blastoma
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Accession:HP:0034921 term browser browse the term
Definition:Pituitary blastoma is a distinctive anterior hypophyseal tumor of infants
Comment:Pituitary blastoma presents in infants younger than 24 months, most frequently with Cushing syndrome and elevated adrenocorticotropin (ACTH) and occasionally with ophthalmoplegia, signs of increased intracranial pressure, diabetes insipidus, and thyrotropin deficit. An often large solid or cystic/solid mass arises from the sella with extension into the hypothalamus and may encompass the optic chiasm and/or cavernous sinuses. Pathologically, the tumors exhibit arrested pituitary development and uncontrolled proliferation and are composed of Rathke epithelium, folliculostellate cells, small primitive cells, and secretory cells with ACTH or, less often, growth hormone immunoexpression.



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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the endocrine system 0
        Neoplasm of the endocrine system 0
          Neoplasm of the pituitary gland 0
            Neoplasm of the anterior pituitary 0
              Pituitary blastoma 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal brain morphology 0
              Abnormal pituitary gland morphology 0
                Neoplasm of the pituitary gland 0
                  Neoplasm of the anterior pituitary 0
                    Pituitary blastoma 0
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