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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Triggered by fava bean ingestion
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Accession:HP:0034060 term browser browse the term
Definition:Applies to a sign or symptom that is provoked or brought about by eating fava beans.
Comment:The fava bean plant (Vicia faba) was probably one of the first plants to be domesticated, V. faba contains high concentrations of two beta-glucosides (up to 2% in dry weight): vicine and convicine. On ingestion of fava beans, vicine and convicine undergo hydrolysis by glucosidases present both in the beans and in the gastrointestinal tract, releasing the respective aglycones: divicine (2,6-diamino-4,5-dihydroxypyrimidine) and isouramil (6-amino-2,4,5-trihydroxypyrimidine). These highly reactive redox compounds have antifungal and pesticide activity, which probably helps prevent fava beans from rotting, but the compounds are also capable of triggering a favism attack in persons with glucose-6-phosphate dehydrogenase (G6PD) deficiency.


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  Human phenotype 0
    Clinical modifier 0
      Triggered by 0
        Triggered by food ingestion 0
          Triggered by fava bean ingestion 0
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