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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Lymphoid nodular hyperplasia
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Accession:HP:0032203 term browser browse the term
Definition:Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236).
Comment:The presence of LNH in the mucosa of the colon and/or terminal ileum is a frequent finding (30%) in children undergoing colonoscopy. Unless associated with other endoscopic lesions, LNH is mostly related to a condition of delayed-type food hypersensitivity and affects mainly preschool or school-age children with hematochezia.
Synonyms:exact_synonym: Lymphonodular hyperplasia of the colon


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormal digestive system morphology 0
          Abnormal gastrointestinal tract morphology 0
            Abnormal intestine morphology 0
              Abnormal large intestine morphology 0
                Lymphoid nodular hyperplasia 0
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