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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Ameliorated by
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Accession:HP:0025254 term browser browse the term
Definition:An ameliorating factor is defined as an external factor that leads to a sign or symptom that is already present improving or becoming more bearable
Synonyms:exact_synonym: Improved by


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Ameliorated by exposure to medication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 treatment IAGP associated with methadone treatment;DNA:SNP:intron (rs1128503) (human) RGD PMID:29173032 RGD:401976557 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ARRB2 arrestin beta 2 treatment IAGP associated with methadone treatment;DNA:SNP:intron (rs1045280) (human) RGD PMID:29173032 RGD:401976557 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G COMT catechol-O-methyltransferase ameliorates IAGP associated with maternal opioid abuse;DNA:SNP:intron (rs740603) (human) RGD PMID:26233486 RGD:11079504 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G OPRD1 opioid receptor delta 1 treatment IAGP associated with methadone treatment;DNA:SNP:intron (rs529520) (human)
associated with alcohol dependence, naltrexone;DNA:SNP:3'UTR (rs4654327) (human)
associated with opiate dependence, methadone;DNA:SNP:cds (rs204076) (human)
associated with cocaine dependence; methadone (ChEBI:6807), disulfiram (ChEBI:4659) (human)
associated with females, buprenorphine;DNA:SNP:intron (rs581111|rs529520) (human)
associated with African American;DNA:SNP:intron (rs678849) (human)		 RGD PMID:29173032 PMID:22954510 PMID:37531661 PMID:33953123 PMID:24126707 More... RGD:401976557, RGD:402528370, RGD:401977581, RGD:402463937, RGD:402463962, RGD:402463973 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRK1 opioid receptor kappa 1 severity
treatment		 IAGP associated with maternal opioid abuse;DNA:SNP:intron (rs702764) (human)
associated with alcohol dependence, naltrexone;DNA:SNP:intron (rs997917) (human)		 RGD PMID:26233486 PMID:22954510 RGD:11079504, RGD:402528370 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRM1 opioid receptor mu 1 ameliorates IAGP associated with maternal opioid abuse;DNA:SNP:intron (rs1799971) (human) RGD PMID:26233486 RGD:11079504 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PNOC prepronociceptin severity IAGP associated with maternal opioid abuse;DNA:SNP:intron (rs732636|rs351776|rs2614095 ) (human) RGD PMID:26233486 RGD:11079504 NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355 		JBrowse link
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