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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Laryngeal cleft
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Accession:HP:0008751 term browser browse the term
Definition:Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esophagus.
Comment:Embryologically, the trachea and esophagus share a common lumen until they are separated by the development of the tracheoesophageal septum. Failure of this fusion and incomplete development of the tracheoesophageal septum may lead to congenital abnormalities such as isolatedlaryngeal cleft, tracheoesophageal fistula, and esophageal atresia, depending on the severity of the abnormality. Patients with laryngeal cleft may present with feeding difficulty, chronic cough, stridor, pneumonia or respiratory distress, depending on the size of the cleft.
Synonyms:exact_synonym: Laryngotracheal cleft;   Laryngotracheoesophageal cleft i
 xref: SNOMEDCT_US:232461002;   UMLS:C1840311


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the respiratory system 0
        Abnormal respiratory system physiology 0
          Abnormal respiratory system morphology 0
            Abnormality of the upper respiratory tract 0
              Abnormality of the larynx 0
                Abnormal larynx morphology 0
                  Laryngeal cleft 0
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