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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormal blistering of the skin
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Accession:HP:0008066 term browser browse the term
Definition:The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.
Comment:A bulla is a large vesicle described as a rounded or irregularly shaped blister containing serous or seropurulent fluid, equal to or greater than 10mm. In approaching blistering diseases, there are 3 fundamental criteria to consider: (1) the site or level of the blister (or the lowest level of vesiculation): subcorneal, midepidermis, suprabasal, subepidermal; (2) the findings that implicate the mechanism of blister formation (spongiosis, acantholysis, blistering degeneration, or epidermolysis); and (3) the type of inflammation (neutrophilic, lymphocytic, eosinophilic, mixed), if present.
Synonyms:exact_synonym: Blister;   Blistering, generalised;   Blistering, generalized;   Blisters;   Skin bullae
 related_synonym: SKIN BLISTERS
 alt_id: HP:0007467;   HP:0007496;   HP:0200038
 xref: UMLS:C0241054;   UMLS:C2132198;   UMLS:C2220104


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the integument 0
        Abnormality of the skin 0
          Abnormal skin morphology 0
            Abnormal blistering of the skin 0
              Blistering by anatomical location + 0
              Blistering by histological location + 0
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