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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Peptic ulcer
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Accession:HP:0004398 term browser browse the term
Definition:The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the esophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers.
Comment:Symptoms of peptic ulcer disease have limited predictive value because they are non-specific. Patients with duodenal ulcers typically feel hungry or have nocturnal abdominal pain. By contrast, patients with gastric ulcers have postprandial abdominal pain, nausea, vomiting, and weight loss. Patients with untreated peptic ulcer disease typically have relapsing symptoms because of spontaneous healing and relapse while the causal factor (eg, H pylori infection or NSAID use) persists.
Synonyms:exact_synonym: Sore in the lining of gastrointestinal tract
 xref: SNOMEDCT_US:13200003;   UMLS:C0030920


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormal digestive system morphology 0
          Abnormal gastrointestinal tract morphology 0
            Gastrointestinal ulcer 0
              Peptic ulcer 0
                Gastric ulcer 0
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