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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Arterial calcification
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Accession:HP:0003207 term browser browse the term
Definition:Pathological deposition of calcium salts in one or more arteries.
Comment:Most individuals aged over 60 years have progressively enlarging deposits of calcium mineral in their major arteries. This vascular calcification reduces aortic and arterial elastance, which impairs cardiovascular hemodynamics, resulting in substantial morbidity and mortality in the form of hypertension, aortic stenosis, cardiac hypertrophy, myocardial and lower-limb ischemia, congestive heart failure, and compromised structural integrity.The severity and extent of mineralization reflect atherosclerotic plaque burden and strongly and independently predict cardiovascular morbidity and mortality. (From PMID:18519861).
Synonyms:alt_id: HP:0012455
 xref: UMLS:C1168153



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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the cardiovascular system 0
        Abnormal cardiovascular system morphology 0
          Cardiovascular calcification 0
            Vascular calcification 0
              Arterial calcification 0
                Calcification of the aorta + 0
                Carotid artery calcification + 0
                Coronary artery calcification 0
                Generalized arterial calcification 0
                Intracranial arterial calcification + 0
                Medial arterial calcification + 0
                Peripheral arterial calcification + 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the skeletal system 0
          Ectopic calcification 0
            Cardiovascular calcification 0
              Vascular calcification 0
                Arterial calcification 0
                  Calcification of the aorta + 0
                  Carotid artery calcification + 0
                  Coronary artery calcification 0
                  Generalized arterial calcification 0
                  Intracranial arterial calcification + 0
                  Medial arterial calcification + 0
                  Peripheral arterial calcification + 0
paths to the root