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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Gliosis
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Accession:HP:0002171 term browser browse the term
Definition:Gliosis is the focal proliferation of glial cells in the central nervous system.
Comment:Gliosis generally occurs as a response to tissue damage. Gliosis appears bright on T2 scans upon magnetic resonance imaging, unlike encephalomalacia which follows CSF signal on all sequences. Glial cells, the non-neuronal component of the central nervous system, are divided into microglia and macroglia. The latter are in turn divided into astrocytes, oligodendrocytes, and ependymal cells. The astrocytes and the microglia are the glial cells predominantly responsible for tissue response to injury.
Synonyms:exact_synonym: Cerebral gliosis;   Excess astrocytes in brain
 xref: SNOMEDCT_US:359580009;   SNOMEDCT_US:81415000;   UMLS:C0017639



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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Abnormal glial cell morphology 0
            Gliosis 0
              Basal ganglia gliosis 0
              Cerebellar gliosis 0
              Hippocampal sclerosis 0
              Hypothalamic gliosis 0
              Myelin-dependent gliosis 0
              Substantia nigra gliosis 0
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