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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Hypersplenism
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Accession:HP:0001971 term browser browse the term
Definition:A malfunctioning of the spleen in which it prematurely destroys red blood cells.
Comment:The spleen normally functions to remove senescent red blood cells (RBCs) from the circulation. Hypersplenism represents a pathological acceleration of this function, resulting in the premature removal from the circulation of RBCs and other cellular components of the blood, often accompanied by an increase in size of the spleen (splenomegaly).
Synonyms:xref: EFO:1000975;   SNOMEDCT_US:58381000;   UMLS:C0020532



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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormality of the abdominal organs 0
          Abnormality of the spleen 0
            Abnormal spleen physiology 0
              Hypersplenism 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the cardiovascular system 0
        Abnormality of the vasculature 0
          Abnormality of the lymphatic system 0
            Abnormality of the spleen 0
              Abnormal spleen physiology 0
                Hypersplenism 0
paths to the root