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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Metabolic acidosis
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Accession:HP:0001942 term browser browse the term
Definition:Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause.
Comment:The Henderson-Hasselbalch method defines metabolic acidosis by the presence of an acid-base imbalance associated with a plasma bicarbonate concentration below 20 mmol/L. The association of this imbalance with decreased pH is called acidemia, which is often described as severe when the pH is equal to or below 7.20. Arterial blood gas measurements can be performed in patients with a decreased plasma bicarbonate level so as to eliminate respiratory alkalosis, confirm the diagnosis of metabolic acidosis, and test for mixed acidosis.
Synonyms:alt_id: HP:0004895;   HP:0004907
 xref: SNOMEDCT_US:59455009;   UMLS:C0220981


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of metabolism/homeostasis 0
        Abnormal homeostasis 0
          Abnormality of acid-base homeostasis 0
            Acidosis 0
              Metabolic acidosis 0
                Chronic metabolic acidosis 0
                Episodic metabolic acidosis 0
                Hyperchloremic metabolic acidosis 0
                Hyperkalemic metabolic acidosis 0
                Metabolic ketoacidosis 0
                Mixed respiratory and metabolic acidosis 0
                Renal tubular acidosis + 0
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