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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cellular senescence
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Accession:GO:2000772 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cellular senescence.


show annotations for term's descendants           Sort by:
regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO
IEA		 MGI:1338938 (PMID:22729085)
GO_REF:0000107		 RGD
Ensembl		 PMID:22729085 GO_REF:0000107 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22101268)		 UniProt
RGD		 PMID:22101268 GO_REF:0000024 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO
IEA		 MGI:87859 (PMID:22729085)
GO_REF:0000107		 RGD
Ensembl		 PMID:22729085 GO_REF:0000107 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (PMID:23686339) RGD PMID:23686339 NCBI chr 5:168,084,487...168,097,519
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
G Nek4 NIMA-related kinase 4 involved_in ISO
IEA		 (PMID:22851694)
GO_REF:0000107		 RGD
Ensembl		 PMID:22851694 GO_REF:0000107 NCBI chr16:6,151,292...6,200,280
Ensembl chr16:6,144,959...6,188,932 		JBrowse link
G Nuak1 NUAK family kinase 1 involved_in ISO
IEA		 (PMID:19927127)
GO_REF:0000107		 RGD
Ensembl		 PMID:19927127 GO_REF:0000107 NCBI chr 7:21,217,729...21,289,608
Ensembl chr 7:19,329,933...19,401,913 		JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 involved_in ISO
IEA		 (PMID:16055741)
GO_REF:0000107		 RGD
Ensembl		 PMID:16055741 GO_REF:0000107 NCBI chr14:107,078,486...107,109,628
Ensembl chr14:102,877,553...102,908,696 		JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 involved_in ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,931,839...4,943,726
Ensembl chr10:4,397,821...4,439,593 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:2445449 (PMID:23695662) RGD PMID:23695662 NCBI chr  X:17,093,059...17,105,942
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO MGI:2445449 (PMID:23695662) RGD PMID:23695662 NCBI chr  X:146,828,818...146,831,485 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA		 MGI:2139971 (PMID:22904064)
GO_REF:0000107		 RGD
Ensembl		 PMID:22904064 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vash1 vasohibin 1 acts_upstream_of_or_within ISO
IEA		 (PMID:23056314)
GO_REF:0000107		 RGD
Ensembl		 PMID:23056314 GO_REF:0000107 NCBI chr 6:112,060,086...112,076,689
Ensembl chr 6:106,329,123...106,345,726 		JBrowse link
G Zfp277 zinc finger protein 277 acts_upstream_of_or_within ISO MGI:5496522 (PMID:20808772) RGD PMID:20808772 NCBI chr 6:63,110,609...63,239,941
Ensembl chr 6:57,383,951...57,512,765 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO
IEA		 MGI:1888594|MGI:2180033 (PMID:16079796), (PMID:21746928), (PMID:23686339)
GO_REF:0000107		 RGD
Ensembl		 PMID:16079796 PMID:21746928 PMID:23686339 GO_REF:0000107 NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:134,627,229...134,660,110 		JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO
IEA		 MGI:104738 (PMID:22729085)
GO_REF:0000107		 RGD
Ensembl		 PMID:22729085 GO_REF:0000107 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO (PMID:25323119) RGD PMID:25323119 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ang angiogenin involved_in ISO (PMID:33758201) RGD PMID:33758201 NCBI chr15:26,786,233...26,796,883 JBrowse link
G Bcl2l12 Bcl2 like 12 acts_upstream_of_or_within ISO
IEA		 (PMID:20837658)
GO_REF:0000107		 RGD
Ensembl		 PMID:20837658 GO_REF:0000107 NCBI chr 1:104,608,753...104,617,472
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA		 MGI:2158436 (PMID:23209284)
GO_REF:0000107		 RGD
Ensembl		 PMID:23209284 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO
IEA		 (PMID:17420273)
GO_REF:0000107		 RGD
Ensembl		 PMID:17420273 GO_REF:0000107 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Fbxo5 F-box protein 5 involved_in ISO
IEA		 (PMID:17875940)
GO_REF:0000107		 RGD
Ensembl		 PMID:17875940 GO_REF:0000107 NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO
IEA		 (PMID:21241890)
GO_REF:0000107		 RGD
Ensembl		 PMID:21241890 GO_REF:0000107 NCBI chr 7:8,982,765...8,994,689
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IMP RGD PMID:30690003 RGD:401717569 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
IEA		 (PMID:23072816)
GO_REF:0000107		 RGD
Ensembl		 PMID:23072816 GO_REF:0000107 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:10562313) RGD PMID:10562313 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Plk2 polo-like kinase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:27908889)		 Ensembl
RGD		 PMID:27908889 GO_REF:0000107 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:21241890) RGD PMID:21241890 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in ISO
IEA		 (PMID:28595801)
GO_REF:0000107		 RGD
Ensembl		 PMID:28595801 GO_REF:0000107 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:20203304), (PMID:20424141)
GO_REF:0000107		 RGD
Ensembl		 PMID:20203304 PMID:20424141 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:22753495), (PMID:27043296), (PMID:29474172) RGD PMID:22753495 PMID:27043296 PMID:29474172 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO
IEA		 (PMID:11062467), (PMID:12000749)
GO_REF:0000107		 RGD
Ensembl		 PMID:11062467 PMID:12000749 GO_REF:0000107 NCBI chr10:71,177,082...71,186,275
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
G Terc telomerase RNA component involved_in ISO (PMID:11313459) RGD PMID:11313459 NCBI chr 2:114,744,148...114,744,535 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IEA		 (PMID:11927518)
GO_REF:0000107		 RGD
Ensembl		 PMID:11927518 GO_REF:0000107 NCBI chr19:51,887,221...51,915,756
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO
IEA		 (PMID:11313459), (PMID:11927518)
GO_REF:0000107		 RGD
Ensembl		 PMID:11313459 PMID:11927518 GO_REF:0000107 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO
IEA		 (PMID:16501043)
GO_REF:0000107		 RGD
Ensembl		 PMID:16501043 GO_REF:0000107 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Ybx1 Y box binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29712925)		 UniProt
RGD		 PMID:29712925 GO_REF:0000024 NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:47,912,816...47,928,553
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family, member 3 involved_in ISO
IEA		 (PMID:21223585)
GO_REF:0000107		 RGD
Ensembl		 PMID:21223585 GO_REF:0000107 NCBI chr10:81,266,571...81,277,561
Ensembl chr10:80,769,822...80,780,816 		JBrowse link
G Abi3bp ABI family member 3 binding protein involved_in ISS GO_REF:0000024 ARUK-UCL GO_REF:0000024 NCBI chr11:57,381,282...57,597,989
Ensembl chr11:43,913,043...44,128,929 		JBrowse link
G Arg2 arginase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22928666)		 Ensembl
RGD		 PMID:22928666 GO_REF:0000107 NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G B2m beta-2 microglobulin involved_in ISO
IEA		 (PMID:28213472)
GO_REF:0000107		 RGD
Ensembl		 PMID:28213472 GO_REF:0000107 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Ccn1 cellular communication network factor 1 IEP RGD PMID:30371213 RGD:329845516 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO
IEA		 (PMID:28759028)
GO_REF:0000107		 RGD
Ensembl		 PMID:28759028 GO_REF:0000107 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 involved_in ISO
IEA		 (PMID:25465621)
GO_REF:0000107		 RGD
Ensembl		 PMID:25465621 GO_REF:0000107 NCBI chr17:26,354,247...26,364,953
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Ilk integrin-linked kinase IMP RGD PMID:17234816 RGD:2301768 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Mir20b microRNA 20b involved_in ISO (PMID:28595801) RGD PMID:28595801 NCBI chr  X:137,343,197...137,343,268
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir217 microRNA 217 involved_in ISO (PMID:19786632) RGD PMID:19786632 NCBI chr14:106,732,485...106,732,589
Ensembl chr14:102,531,505...102,531,609 		JBrowse link
G Mir22 microRNA 22 involved_in ISO (PMID:25323119) RGD PMID:25323119 NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:20424141) RGD PMID:20424141 NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Morc3 MORC family CW-type zinc finger 3 acts_upstream_of_or_within ISO
IEA		 (PMID:17332504)
GO_REF:0000107		 RGD
Ensembl		 PMID:17332504 GO_REF:0000107 NCBI chr11:46,621,575...46,664,315
Ensembl chr11:33,152,025...33,194,646 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19698731 RGD:10003167 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (PMID:25472717) RGD PMID:25472717 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:23184984) RGD PMID:23184984 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:18687677)
GO_REF:0000107		 RGD
Ensembl		 PMID:18687677 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:29474172)
GO_REF:0000107
MGI:1920086 (PMID:17053789)
(PMID:10562313)		 RGD
Ensembl		 PMID:10562313 PMID:17053789 PMID:29474172 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ypel3 yippee-like 3 involved_in ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:181,384,357...181,387,705 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      regulation of cellular process 13030
        regulation of cellular senescence 59
          negative regulation of cellular senescence 27
          positive regulation of cellular senescence 21
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular response to stimulus 8963
        cellular response to stress 2072
          cellular senescence 108
            regulation of cellular senescence 59
              negative regulation of cellular senescence 27
              positive regulation of cellular senescence 21
paths to the root