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ONTOLOGY REPORT - ANNOTATIONS

Term:ligand-gated ion channel signaling pathway
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Accession:GO:1990806 term browser browse the term
Definition:The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: ligand-gated ion channel signalling pathway


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ligand-gated ion channel signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa7 annexin A7 acts_upstream_of_or_within_positive_effect ISO MGI:2159005 (PMID:10570150) RGD PMID:10570150 NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,821,845...3,849,385 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 involved_in ISO (PMID:20440069) RGD PMID:20440069 NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IDA
ISO		 PMID:22250215
(PMID:33735609)		 RGD PMID:33735609 PMID:22250215 RGD:597976624 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G F2 coagulation factor II, thrombin involved_in IEA
ISO		 GO_REF:0000107
(PMID:26742564)		 Ensembl
RGD		 PMID:26742564 GO_REF:0000107 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 involved_in ISO MGI:88380 (PMID:26742564) RGD PMID:26742564 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
G Ffar1 free fatty acid receptor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:31664108)		 Ensembl
RGD		 PMID:31664108 GO_REF:0000107 NCBI chr 1:95,238,785...95,239,689
Ensembl chr 1:86,111,368...86,112,272 		JBrowse link
G Ffar2 free fatty acid receptor 2 involved_in ISO
IEA		 (PMID:26075576)
GO_REF:0000107		 RGD
Ensembl		 PMID:26075576 GO_REF:0000107 NCBI chr 1:95,199,277...95,202,599
Ensembl chr 1:86,072,184...86,075,033 		JBrowse link
G Gna11 G protein subunit alpha 11 involved_in IEA
ISO		 GO_REF:0000107
MGI:95776 (PMID:20440069), (PMID:26075576)		 Ensembl
RGD		 PMID:20440069 PMID:26075576 GO_REF:0000107 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q involved_in ISO MGI:95766 (PMID:20440069), (PMID:26075576) RGD PMID:20440069 PMID:26075576 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:88031 (PMID:10570150), (PMID:26075576), (PMID:31664108)		 Ensembl
RGD		 PMID:10570150 PMID:26075576 PMID:31664108 GO_REF:0000107 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO (PMID:31664108) RGD PMID:31664108 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:6460327 (PMID:26075576), (PMID:31268747)		 Ensembl
RGD		 PMID:26075576 PMID:31268747 GO_REF:0000107 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO MGI:5008476 (PMID:18452988), (PMID:30131394), (PMID:31664108) RGD PMID:18452988 PMID:30131394 PMID:31664108 NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
AMPA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in IEA
ISO		 GO_REF:0000107
ComplexPortal:CPX-1070 (PMID:20395454)		 Ensembl
RGD		 PMID:20395454 GO_REF:0000107 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISS
ISO		 GO_REF:0000024
(PMID:18599438)		 Alzheimers_University_of_Toronto
RGD		 PMID:18599438 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA PMID:17582332 BHF-UCL PMID:17582332 RGD:8553502 NCBI chr 2:110,184,987...111,110,316
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nrxn1 neurexin 1 acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:19098102), (PMID:20869594)		 BHF-UCL
RGD		 PMID:19098102 PMID:20869594 GO_REF:0000024 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Plp1 proteolipid protein 1 IMP RGD PMID:16510724 RGD:30296668 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 acts_upstream_of_positive_effect ISS GO_REF:0000024 BHF-UCL GO_REF:0000024 NCBI chr 1:103,944,416...103,993,887
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
ionotropic glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2652346 (PMID:16025111)		 UniProt
RGD		 PMID:16025111 GO_REF:0000024 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO MGI:3696954 (PMID:17234593) RGD PMID:17234593 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha involved_in IDA PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in IDA PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin acts_upstream_of_or_within ISO
IEA		 MGI:1933976 (PMID:16483786)
GO_REF:0000107		 RGD
Ensembl		 PMID:16483786 GO_REF:0000107 NCBI chr 1:190,586,649...190,600,034
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 involved_in IDA PMID:20937770 UniProt PMID:20937770 RGD:8553637 NCBI chr10:16,222,271...16,284,248
Ensembl chr10:15,717,794...15,780,603 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase TAS RGD PMID:12736333 RGD:1358550 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 involved_in ISO
IEA
ISS		 (PMID:20614889)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20614889 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,138,925...10,885,808 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 IDA RGD PMID:17395219 RGD:1642466 NCBI chr11:40,655,974...41,056,966
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:143,052,442...143,268,873
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:51,802,045...52,228,751
Ensembl chr 8:42,905,056...43,193,751 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA
ISS		 GO_REF:0000117
(PMID:16025111)
GO_REF:0000033
GO_REF:0000114
PMID:19793963
(PMID:28228639)		 UniProt
RGD
GO_Central
ComplexPortal		 PMID:16025111 PMID:28228639 PMID:16477151 PMID:19793963 GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:1642190, RGD:150521643 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in IDA
ISS
IEA		 GO_REF:0000114
PMID:19793963
GO_REF:0000108		 ComplexPortal
GOC
RGD		 PMID:16477151 PMID:19793963 GO_REF:0000108 GO_REF:0000114, RGD:1642190, RGD:150521643 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in IDA
ISS
IEA		 GO_REF:0000114
GO_REF:0000108
PMID:19793963		 ComplexPortal
GOC
RGD		 PMID:16477151 PMID:19793963 GO_REF:0000108 GO_REF:0000114, RGD:1642190, RGD:150521643 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C involved_in IEA
IDA		 GO_REF:0000108
PMID:19793963		 GOC PMID:19793963 GO_REF:0000108, RGD:150521643 NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D involved_in IDA PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A involved_in IDA
IEA
IBA		 GO_REF:0000108
GO_REF:0000033		 GOC
GO_Central
RGD		 PMID:16477151 GO_REF:0000033 GO_REF:0000108, RGD:1642190 NCBI chr 5:68,802,333...69,001,880
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11823786 GO_REF:0000033, RGD:632842 NCBI chr 7:10,381,495...10,387,817
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP PMID:15814199 Alzheimers_University_of_Toronto PMID:15814199 RGD:8655534 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
NMDA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dorip1 dopamine receptor interacting protein 1 acts_upstream_of_or_within_positive_effect ISO
IEA		 (PMID:37248637)
GO_REF:0000107		 RGD
Ensembl		 PMID:37248637 GO_REF:0000107 NCBI chr 6:88,701,651...88,710,204
Ensembl chr 6:82,965,328...82,972,558 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISS
ISO		 GO_REF:0000024
(PMID:18599438)		 Alzheimers_University_of_Toronto
RGD		 PMID:18599438 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA
IMP		 PMID:17582332
PMID:25428619		 BHF-UCL
ARUK-UCL		 PMID:17582332 PMID:25428619 RGD:8553502, RGD:11554338 NCBI chr 2:110,184,987...111,110,316
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nrxn1 neurexin 1 acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:19098102)		 BHF-UCL
RGD		 PMID:19098102 GO_REF:0000024 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
serotonin-gated cation-selective signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A involved_in IEA
ISO		 GO_REF:0000107
(PMID:10521471)		 Ensembl
RGD		 PMID:10521471 GO_REF:0000107 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B involved_in IEA
ISO		 GO_REF:0000107
(PMID:9950429)		 Ensembl
RGD		 PMID:9950429 GO_REF:0000107 NCBI chr 8:58,175,785...58,204,939
Ensembl chr 8:49,279,173...49,308,444 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      signal transduction 7313
        ligand-gated ion channel signaling pathway 49
          ionotropic glutamate receptor signaling pathway + 34
          serotonin-gated cation-selective signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 20567
    biological regulation 13841
      regulation of biological process 13403
        signaling 7874
          signal transduction 7313
            ligand-gated ion channel signaling pathway 49
              ionotropic glutamate receptor signaling pathway + 34
              serotonin-gated cation-selective signaling pathway 2
paths to the root