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ONTOLOGY REPORT - ANNOTATIONS

Term:mitotic spindle assembly checkpoint MAD1-MAD2 complex
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Accession:GO:1990728 term browser browse the term
Definition:A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.
Comment:An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
Synonyms:exact_synonym: MAD1-MAD2 complex


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mitotic spindle assembly checkpoint MAD1-MAD2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 part_of ISO (PMID:12006501) RGD PMID:12006501 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 part_of ISO (PMID:12006501) RGD PMID:12006501 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20833
    protein-containing complex 6558
      mitotic spindle assembly checkpoint MAD1-MAD2 complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20833
    cellular anatomical structure 20633
      intracellular anatomical structure 15189
        cytoplasm 11893
          mitotic spindle assembly checkpoint MAD1-MAD2 complex 2
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